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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2004-4-16
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pubmed:abstractText |
No replacement for succinylcholine is yet available. GW280430A (AV430A) is a representative of a new class of nondepolarizing neuromuscular blocking drugs called asymmetric mixed-onium chlorofumarates. It undergoes rapid degradation in plasma by chemical hydrolysis and inactivation by cysteine adduction, resulting in a very short duration of effect. The neuromuscular, cardiovascular, and autonomic pharmacology of GW280430A is compared herein with that of mivacurium.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0003-3022
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pubmed:author |
pubmed-author:BelmontMatthew RMR,
pubmed-author:BorosEric EEE,
pubmed-author:CohnDouglas LDL,
pubmed-author:FeldmanPaul LPL,
pubmed-author:HashimMir AMA,
pubmed-author:McNultyMichaelM,
pubmed-author:MookRobert ARAJr,
pubmed-author:MorganPhilipP,
pubmed-author:PatelSanjay SSS,
pubmed-author:SamanoVicenteV,
pubmed-author:SavareseJohn JJJ,
pubmed-author:SchultzJan-Ake IJA,
pubmed-author:SpitzerTimothyT,
pubmed-author:WastilaWilliam BWB
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pubmed:issnType |
Print
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pubmed:volume |
100
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
835-45
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pubmed:dateRevised |
2009-8-6
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pubmed:meshHeading |
pubmed-meshheading:15087618-Animals,
pubmed-meshheading:15087618-Blood Pressure,
pubmed-meshheading:15087618-Cats,
pubmed-meshheading:15087618-Dose-Response Relationship, Drug,
pubmed-meshheading:15087618-Heart Rate,
pubmed-meshheading:15087618-Isoquinolines,
pubmed-meshheading:15087618-Macaca mulatta,
pubmed-meshheading:15087618-Male,
pubmed-meshheading:15087618-Neuromuscular Junction,
pubmed-meshheading:15087618-Neuromuscular Nondepolarizing Agents,
pubmed-meshheading:15087618-Structure-Activity Relationship,
pubmed-meshheading:15087618-Terminology as Topic,
pubmed-meshheading:15087618-Time Factors
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pubmed:year |
2004
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pubmed:articleTitle |
Preclinical pharmacology of GW280430A (AV430A) in the rhesus monkey and in the cat: a comparison with mivacurium.
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pubmed:affiliation |
Department of Anesthesiology, Weill Medical College of Cornell University and New York-Presbyterian Hospital, New York, New York 10021, USA. jjsavare@med.cornell.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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