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rdf:type |
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lifeskim:mentions |
umls-concept:C0003018,
umls-concept:C0015385,
umls-concept:C0017262,
umls-concept:C0086418,
umls-concept:C0175677,
umls-concept:C0185117,
umls-concept:C0205385,
umls-concept:C0311404,
umls-concept:C0442805,
umls-concept:C0538674,
umls-concept:C0599946,
umls-concept:C2911684
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pubmed:issue |
5
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pubmed:dateCreated |
2004-4-16
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pubmed:abstractText |
Heme oxygenase-1 (HO-1) catalyzes the conversion of heme to bilirubin, carbon monoxide (CO), and free iron, thus controlling the level of cellular heme. The medullary thick ascending limb of the loop of Henle (TALH) is situated in a site of markedly diminished oxygen tension and, as such, is highly vulnerable to ischemic insult. We hypothesize that selective upregulation of HO-1 in TALH by gene transfer attenuates oxidative stress caused by angiotensin II (Ang II).
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione,
http://linkedlifedata.com/resource/pubmed/chemical/HMOX1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Heme,
http://linkedlifedata.com/resource/pubmed/chemical/Heme Oxygenase (Decyclizing),
http://linkedlifedata.com/resource/pubmed/chemical/Heme Oxygenase-1,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium-Potassium-Chloride Symporters,
http://linkedlifedata.com/resource/pubmed/chemical/heme oxygenase-2,
http://linkedlifedata.com/resource/pubmed/chemical/sodium-potassium chloride...
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0085-2538
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1628-39
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15086901-Angiotensin II,
pubmed-meshheading:15086901-Animals,
pubmed-meshheading:15086901-Base Sequence,
pubmed-meshheading:15086901-Cells, Cultured,
pubmed-meshheading:15086901-Cyclooxygenase 2,
pubmed-meshheading:15086901-DNA, Complementary,
pubmed-meshheading:15086901-DNA Damage,
pubmed-meshheading:15086901-Dinoprostone,
pubmed-meshheading:15086901-Gene Expression,
pubmed-meshheading:15086901-Glutathione,
pubmed-meshheading:15086901-Heme,
pubmed-meshheading:15086901-Heme Oxygenase (Decyclizing),
pubmed-meshheading:15086901-Heme Oxygenase-1,
pubmed-meshheading:15086901-Humans,
pubmed-meshheading:15086901-Isoenzymes,
pubmed-meshheading:15086901-Loop of Henle,
pubmed-meshheading:15086901-Membrane Proteins,
pubmed-meshheading:15086901-Oxidative Stress,
pubmed-meshheading:15086901-Promoter Regions, Genetic,
pubmed-meshheading:15086901-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:15086901-Rats,
pubmed-meshheading:15086901-Recombinant Proteins,
pubmed-meshheading:15086901-Sodium-Potassium-Chloride Symporters,
pubmed-meshheading:15086901-Transduction, Genetic
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pubmed:year |
2004
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pubmed:articleTitle |
Expression of human heme oxygenase-1 in the thick ascending limb attenuates angiotensin II-mediated increase in oxidative injury.
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pubmed:affiliation |
Department of Pharmacology, Division of Nephrology, New York Medical College, Valhalla, New York 10595, USA. nader_abraham@nymc.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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