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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2004-4-16
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pubmed:abstractText |
Attachment of Helicobacter pylori to gastric epithelial cells leads to the production of chemokines, such as interleukin-8 (IL-8), which in turn activate and recruit neutrophils to the site of infection. Lafutidine [(+/-)-2-(furfurylsulfinyl)-N-(4-(4-(piperidinomethyl)-2-pyridyl)oxy-(Z)-2-butenyl)acetamide] is a new type of antiulcer drug that possesses an antisecretory action as well as gastroprotective activity, independent of its antisecretory action. In the present study, we examined the effects of lafutidine on H. pylori-induced IL-8 release and H. pylori adhesion to MKN45 cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0815-9319
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
506-11
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:15086593-Acetamides,
pubmed-meshheading:15086593-Anti-Ulcer Agents,
pubmed-meshheading:15086593-Bacterial Adhesion,
pubmed-meshheading:15086593-Cell Line,
pubmed-meshheading:15086593-Cells, Cultured,
pubmed-meshheading:15086593-Gastric Mucosa,
pubmed-meshheading:15086593-Helicobacter pylori,
pubmed-meshheading:15086593-Humans,
pubmed-meshheading:15086593-Interleukin-1,
pubmed-meshheading:15086593-Interleukin-6,
pubmed-meshheading:15086593-Interleukin-8,
pubmed-meshheading:15086593-Piperidines,
pubmed-meshheading:15086593-Pyridines,
pubmed-meshheading:15086593-Tumor Necrosis Factor-alpha
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pubmed:year |
2004
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pubmed:articleTitle |
Lafutidine inhibits Helicobacter pylori-induced interleukin-8 production in human gastric epithelial cells.
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pubmed:affiliation |
Pharmacobioregulation Research Laboratory, Taiho Pharmaceutical Co. Ltd, 1-27 Misugidai, Hanno-shi, Saitama 357-8527, Japan. y-nozawa@taiho.co.jp
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pubmed:publicationType |
Journal Article
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