Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2004-4-14
pubmed:abstractText
We have discovered a microbial interaction between yeast, bacteria, and nematodes. Upon coculturing, Saccharomyces cerevisiae stimulated the growth of several species of Acinetobacter, including, A. baumannii, A. haemolyticus, A. johnsonii, and A. radioresistens, as well as several natural isolates of Acinetobacter. This enhanced growth was due to a diffusible factor that was shown to be ethanol by chemical assays and evaluation of strains lacking ADH1, ADH3, and ADH5, as all three genes are involved in ethanol production by yeast. This effect is specific to ethanol: methanol, butanol, and dimethyl sulfoxide were unable to stimulate growth to any appreciable level. Low doses of ethanol not only stimulated growth to a higher cell density but also served as a signaling molecule: in the presence of ethanol, Acinetobacter species were able to withstand the toxic effects of salt, indicating that ethanol alters cell physiology. Furthermore, ethanol-fed A. baumannii displayed increased pathogenicity when confronted with a predator, Caenorhabditis elegans. Our results are consistent with the concept that ethanol can serve as a signaling molecule which can affect bacterial physiology and survival.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-10051655, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-10344248, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-10514571, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-10707068, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-10791723, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-11407115, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-11544224, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-11934619, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-12438649, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-12660152, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-12670684, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-12702333, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-13344431, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-2193925, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-2943982, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-3333454, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-3546317, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-360969, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-3690423, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-390364, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-4563985, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-4589126, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-4866103, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-4874313, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-5650064, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-5686604, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-5781579, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-5969497, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-673004, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-6758774, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-7574633, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-8013903, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-8964033, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-9303951, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-9629969, http://linkedlifedata.com/resource/pubmed/commentcorrection/15082781-9892699
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0270-7306
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3874-84
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Microbial synergy via an ethanol-triggered pathway.
pubmed:affiliation
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA.
pubmed:publicationType
Journal Article