|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1-2
|
|
pubmed:dateCreated |
2004-4-14
|
|
pubmed:abstractText |
Thioredoxin (TRX) superfamily proteins that contain a conserved redox-active site -Cys-Xa.a.-Xa.a.-Cys- includes proinflammatory cytokine, macrophage migration inhibiting factor (MIF) and the immune regulatory cytokine, glycosylation inhibiting factor (GIF) in which Cys-60 is cysteinylated. In this report, we have analyzed the functional interaction between TRX and MIF/GIF. The stable Jurkat T cell line transfected with human TRX gene (TRX-transfectant) was highly resistant to hydrogen peroxide-induced apoptosis, but not the cell line transfected with vector (mock-transfectant). The expression level of MIF/GIF protein of TRX-transfectant was lower than that of mock-transfectant. Conversely, the expression level of intracellular TRX protein in CD4(+)-T cells derived from MIF -/- mice were significantly higher than that from background BALB/c mice. These findings collectively suggest that oxidative stress-induced apoptosis on T lymphocytes might be protected by the reciprocal regulation of TRX and MIF/GIF expression.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0165-2478
|
|
pubmed:author |
pubmed-author:IshiiYasuyukiY,
pubmed-author:KondoNorihikoN,
pubmed-author:KwonYong-WonYW,
pubmed-author:MatsuoYoshiyukiY,
pubmed-author:NakayamaToshinoriT,
pubmed-author:NishinakaYumikoY,
pubmed-author:Sakakura-NishiyamaJunkoJ,
pubmed-author:TaniguchiMasaruM,
pubmed-author:TanitoMasakiM,
pubmed-author:YENH CHC,
pubmed-author:YodoiJunjiJ
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
29
|
|
pubmed:volume |
92
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
143-7
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:15081538-Animals,
pubmed-meshheading:15081538-Apoptosis,
pubmed-meshheading:15081538-Cysteine,
pubmed-meshheading:15081538-Humans,
pubmed-meshheading:15081538-Hydrogen Peroxide,
pubmed-meshheading:15081538-Intramolecular Oxidoreductases,
pubmed-meshheading:15081538-Jurkat Cells,
pubmed-meshheading:15081538-Lymphokines,
pubmed-meshheading:15081538-Macrophage Migration-Inhibitory Factors,
pubmed-meshheading:15081538-Mice,
pubmed-meshheading:15081538-Multigene Family,
pubmed-meshheading:15081538-T-Lymphocytes,
pubmed-meshheading:15081538-Thioredoxins
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Cysteine-dependent immune regulation by TRX and MIF/GIF family proteins.
|
|
pubmed:affiliation |
Department of Biological Responses, Institute of Virus Research, Kyoto University, Kyoto, Japan.
|
|
pubmed:publicationType |
Journal Article
|
