| pubmed-article:15081425 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15081425 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:15081425 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:15081425 | lifeskim:mentions | umls-concept:C0017638 | lld:lifeskim |
| pubmed-article:15081425 | lifeskim:mentions | umls-concept:C0288472 | lld:lifeskim |
| pubmed-article:15081425 | lifeskim:mentions | umls-concept:C1514559 | lld:lifeskim |
| pubmed-article:15081425 | lifeskim:mentions | umls-concept:C0079419 | lld:lifeskim |
| pubmed-article:15081425 | lifeskim:mentions | umls-concept:C0249197 | lld:lifeskim |
| pubmed-article:15081425 | lifeskim:mentions | umls-concept:C1420626 | lld:lifeskim |
| pubmed-article:15081425 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:15081425 | lifeskim:mentions | umls-concept:C1517339 | lld:lifeskim |
| pubmed-article:15081425 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:15081425 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15081425 | lifeskim:mentions | umls-concept:C0683461 | lld:lifeskim |
| pubmed-article:15081425 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15081425 | pubmed:dateCreated | 2004-4-14 | lld:pubmed |
| pubmed-article:15081425 | pubmed:abstractText | The regulator of fibroblast growth factor 2 (FGF-2) transcription (RFT) has been reported to be a transcriptional repressor of FGF-2 and induce glioma cell death by its overexpression. Here we report that RFT regulates cell cycle as well as apoptosis by a novel mechanism. RFT expressed in some glioma cell lines, U138MG and T98G, but neither in U87MG nor U251MG. Overexpressed RFT-induced apoptosis in U87MG and U138MG with functioning-type p53 but neither in U251MG nor T98G with non-functioning-type p53. Administration of FGF-2 failed to prevent RFT-induced apoptosis. Overexpression of RFT caused G1-S arrest and upregulated both the phosphorylation of p53 at Ser-15 and the expression level of p21(Waf1). Furthermore, RNAi knockdown of p53 abolished RFT-induced apoptosis in U87MG. Taken together, our results support that RFT regulates G1-S transition and apoptosis via p53/p21(Waf1) pathway. | lld:pubmed |
| pubmed-article:15081425 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15081425 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15081425 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15081425 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15081425 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15081425 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15081425 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15081425 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15081425 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15081425 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15081425 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15081425 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15081425 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15081425 | pubmed:month | May | lld:pubmed |
| pubmed-article:15081425 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:15081425 | pubmed:author | pubmed-author:HashimotoNobu... | lld:pubmed |
| pubmed-article:15081425 | pubmed:author | pubmed-author:NozakiKazuhik... | lld:pubmed |
| pubmed-article:15081425 | pubmed:author | pubmed-author:KageyamaRyoic... | lld:pubmed |
| pubmed-article:15081425 | pubmed:author | pubmed-author:TakahashiJun... | lld:pubmed |
| pubmed-article:15081425 | pubmed:author | pubmed-author:UebaTetsuyaT | lld:pubmed |
| pubmed-article:15081425 | pubmed:author | pubmed-author:ArakawaYoshik... | lld:pubmed |
| pubmed-article:15081425 | pubmed:author | pubmed-author:KawabataYasuh... | lld:pubmed |
| pubmed-article:15081425 | pubmed:author | pubmed-author:KanoHideyukiH | lld:pubmed |
| pubmed-article:15081425 | pubmed:author | pubmed-author:TakatsukaKenj... | lld:pubmed |
| pubmed-article:15081425 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15081425 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:15081425 | pubmed:volume | 317 | lld:pubmed |
| pubmed-article:15081425 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15081425 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15081425 | pubmed:pagination | 902-8 | lld:pubmed |
| pubmed-article:15081425 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15081425 | pubmed:meshHeading | pubmed-meshheading:15081425... | lld:pubmed |
| pubmed-article:15081425 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15081425 | pubmed:articleTitle | Overexpression of RFT induces G1-S arrest and apoptosis via p53/p21(Waf1) pathway in glioma cell. | lld:pubmed |
| pubmed-article:15081425 | pubmed:affiliation | Department of Neurosurgery, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto 606-8315, Japan. | lld:pubmed |
| pubmed-article:15081425 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15081425 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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