Source:http://linkedlifedata.com/resource/pubmed/id/15081385
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2004-4-14
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pubmed:abstractText |
Free fatty acids (FFAs), especially polyunsaturated fatty acids (PUFAs), are potent modulators of muscle-type sodium channels. It is not known if they also modulate sodium channels of sensory neurons. In this study, we investigated the effects of FFAs on the fast tetrodotoxin-sensitive (fTTX-S) and the slow tetrodotoxin-resistant (sTTX-R) sodium currents in rat dorsal root ganglion neurons. At a holding potential of -80 mV, PUFAs potently inhibited fTTX-S current, but monounsaturated fatty acids (MUFAs) and saturated fatty acids (SFAs) to a lesser extent. All FFAs initially increased sTTX-R current, and then decreased it slightly. PUFAs and MUFAs produced a hyperpolarizing shift of the steady-state inactivation voltage for both types of sodium currents. The shift generally increased with the number of unsaturated bonds. FFAs did not change the maximum amplitude of fTTX-S current, but increased that of sTTX-R current. Most FFAs shifted the activation voltage for fTTX-S current in the hyperpolarizing direction, which was not dependent on the degree of unsaturation. MUFAs and SFAs shifted the activation voltage for sTTX-R current in the hyperpolarizing direction, but PUFAs were without effect. The modulation of sodium currents by FFAs, especially PUFAs, may have considerable impact on the excitability of sensory neurons.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrodotoxin
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0006-8993
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
1008
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
81-91
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15081385-Animals,
pubmed-meshheading:15081385-Animals, Newborn,
pubmed-meshheading:15081385-Cells, Cultured,
pubmed-meshheading:15081385-Dose-Response Relationship, Drug,
pubmed-meshheading:15081385-Electric Conductivity,
pubmed-meshheading:15081385-Fatty Acids,
pubmed-meshheading:15081385-Ganglia, Spinal,
pubmed-meshheading:15081385-Ion Channel Gating,
pubmed-meshheading:15081385-Membrane Potentials,
pubmed-meshheading:15081385-Neurons,
pubmed-meshheading:15081385-Patch-Clamp Techniques,
pubmed-meshheading:15081385-Rats,
pubmed-meshheading:15081385-Sodium,
pubmed-meshheading:15081385-Sodium Channel Blockers,
pubmed-meshheading:15081385-Sodium Channels,
pubmed-meshheading:15081385-Tetrodotoxin
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pubmed:year |
2004
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pubmed:articleTitle |
Effects of free fatty acids on sodium currents in rat dorsal root ganglion neurons.
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pubmed:affiliation |
Department of Pharmacology, Chung-Ang University, College of Medicine, 221 Heuk-Suk Dong, Dong-Jak Ku, Seoul 156-756, South Korea.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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