Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2004-4-14
pubmed:abstractText
Eight patients with paraneoplastic cerebellar degeneration (PCD) and anti-Yo antibodies were investigated to determine whether there is any association between cytotoxic T lymphocyte (CTL) responses reactive with two previously defined Yo-derived, HLA-A2.1 restricted epitopes (cdr2-1 and cdr2-2) and the presence of tumour-infiltrating CD8+ CTLs. cdr2-1 and cdr2-2-specific CTL responses could not be detected in 5 HLA-A2.1(+) patients in an ex vivo interferon-gamma ELISPOT assay and only 2/9 tumour sections contained CD8(+) intratumoural lymphocytes suggesting a very limited role for CTL-mediated tumour immunity in this patient group, all of whom had evidence of widespread malignancy at the time of diagnosis and/or death.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0165-5728
pubmed:author
pubmed:issnType
Print
pubmed:volume
150
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
98-106
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:15081253-Antibodies, Neoplasm, pubmed-meshheading:15081253-Breast Neoplasms, pubmed-meshheading:15081253-Cerebellar Neoplasms, pubmed-meshheading:15081253-Cytotoxicity Tests, Immunologic, pubmed-meshheading:15081253-DNA-Binding Proteins, pubmed-meshheading:15081253-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:15081253-Epitopes, T-Lymphocyte, pubmed-meshheading:15081253-Female, pubmed-meshheading:15081253-HLA-A2 Antigen, pubmed-meshheading:15081253-Humans, pubmed-meshheading:15081253-Immunohistochemistry, pubmed-meshheading:15081253-Interferon-gamma, pubmed-meshheading:15081253-Lymphocyte Count, pubmed-meshheading:15081253-Lymphocytes, Tumor-Infiltrating, pubmed-meshheading:15081253-Neoplasm Proteins, pubmed-meshheading:15081253-Nerve Tissue Proteins, pubmed-meshheading:15081253-Ovarian Neoplasms, pubmed-meshheading:15081253-Paraneoplastic Cerebellar Degeneration, pubmed-meshheading:15081253-Protein Isoforms, pubmed-meshheading:15081253-Staining and Labeling, pubmed-meshheading:15081253-T-Lymphocytes, Cytotoxic
pubmed:year
2004
pubmed:articleTitle
An interferon-gamma ELISPOT and immunohistochemical investigation of cytotoxic T lymphocyte-mediated tumour immunity in patients with paraneoplastic cerebellar degeneration and anti-Yo antibodies.
pubmed:affiliation
Department of Neurology, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK. iansutton@email.com
pubmed:publicationType
Journal Article