rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2004-4-14
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pubmed:abstractText |
Eight patients with paraneoplastic cerebellar degeneration (PCD) and anti-Yo antibodies were investigated to determine whether there is any association between cytotoxic T lymphocyte (CTL) responses reactive with two previously defined Yo-derived, HLA-A2.1 restricted epitopes (cdr2-1 and cdr2-2) and the presence of tumour-infiltrating CD8+ CTLs. cdr2-1 and cdr2-2-specific CTL responses could not be detected in 5 HLA-A2.1(+) patients in an ex vivo interferon-gamma ELISPOT assay and only 2/9 tumour sections contained CD8(+) intratumoural lymphocytes suggesting a very limited role for CTL-mediated tumour immunity in this patient group, all of whom had evidence of widespread malignancy at the time of diagnosis and/or death.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/CDR2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A2 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0165-5728
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
150
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
98-106
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15081253-Antibodies, Neoplasm,
pubmed-meshheading:15081253-Breast Neoplasms,
pubmed-meshheading:15081253-Cerebellar Neoplasms,
pubmed-meshheading:15081253-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:15081253-DNA-Binding Proteins,
pubmed-meshheading:15081253-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:15081253-Epitopes, T-Lymphocyte,
pubmed-meshheading:15081253-Female,
pubmed-meshheading:15081253-HLA-A2 Antigen,
pubmed-meshheading:15081253-Humans,
pubmed-meshheading:15081253-Immunohistochemistry,
pubmed-meshheading:15081253-Interferon-gamma,
pubmed-meshheading:15081253-Lymphocyte Count,
pubmed-meshheading:15081253-Lymphocytes, Tumor-Infiltrating,
pubmed-meshheading:15081253-Neoplasm Proteins,
pubmed-meshheading:15081253-Nerve Tissue Proteins,
pubmed-meshheading:15081253-Ovarian Neoplasms,
pubmed-meshheading:15081253-Paraneoplastic Cerebellar Degeneration,
pubmed-meshheading:15081253-Protein Isoforms,
pubmed-meshheading:15081253-Staining and Labeling,
pubmed-meshheading:15081253-T-Lymphocytes, Cytotoxic
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pubmed:year |
2004
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pubmed:articleTitle |
An interferon-gamma ELISPOT and immunohistochemical investigation of cytotoxic T lymphocyte-mediated tumour immunity in patients with paraneoplastic cerebellar degeneration and anti-Yo antibodies.
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pubmed:affiliation |
Department of Neurology, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK. iansutton@email.com
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pubmed:publicationType |
Journal Article
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