| pubmed-article:15081219 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15081219 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:15081219 | lifeskim:mentions | umls-concept:C0085104 | lld:lifeskim |
| pubmed-article:15081219 | lifeskim:mentions | umls-concept:C0102137 | lld:lifeskim |
| pubmed-article:15081219 | lifeskim:mentions | umls-concept:C0063083 | lld:lifeskim |
| pubmed-article:15081219 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:15081219 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:15081219 | lifeskim:mentions | umls-concept:C0061198 | lld:lifeskim |
| pubmed-article:15081219 | lifeskim:mentions | umls-concept:C0527332 | lld:lifeskim |
| pubmed-article:15081219 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15081219 | pubmed:dateCreated | 2004-4-14 | lld:pubmed |
| pubmed-article:15081219 | pubmed:abstractText | A novel pH-sensitive hydrogel system composed of a water-soluble chitosan derivative (N,O-carboxymethyl chitosan, NOCC) and alginate blended with genipin was developed for controlling protein drug delivery. Genipin, a naturally occurring cross-linking agent, is significantly less cytotoxic than glutaraldehyde and may provide a less extent of cross-linking to form a semiinterpenetrating polymeric network (semi-IPN) within the developed hydrogel system. The drug-loading process used in the study was simple and mild. All procedures used were performed in aqueous medium at neutral environment. In the study, preparation of the NOCC/alginate-based hydrogels was reported. Swelling characteristics of these hydrogels as a function of pH values were investigated. Additionally, release profiles of a model protein drug (bovine serum albumin, BSA) from test hydrogels were studied in simulated gastric and intestinal media. The semi-IPN formation of the genipin-cross-linked NOCC/alginate hydrogel was confirmed by means of the scanning electron microscopy-energy dispersive X-ray spectrometer (SEM-EDS) and the ninhydrin assays. The percentage of decrease of free amino groups and cross-linking density for the NOCC/alginate hydrogel cross-linked with 0.75 mM genipin were 18% and 26 mol/m(3), respectively. At pH 1.2, the swelling ratio of the genipin-cross-linked NOCC/alginate hydrogel was limited (2.5) due to formation of hydrogen bonds between NOCC and alginate. At pH 7.4, the carboxylic acid groups on the genipin-cross-linked NOCC/alginate hydrogel became progressively ionized. In this case, the hydrogel swelled more significantly (6.5) due to a large swelling force created by the electrostatic repulsion between the ionized acid groups. The amount of BSA released at pH 1.2 was relatively low (20%), while that released at pH 7.4 increased significantly (80%). The results clearly suggested that the genipin-cross-linked NOCC/alginate hydrogel could be a suitable polymeric carrier for site-specific protein drug delivery in the intestine. | lld:pubmed |
| pubmed-article:15081219 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15081219 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15081219 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15081219 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15081219 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15081219 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15081219 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15081219 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15081219 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15081219 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15081219 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15081219 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15081219 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15081219 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15081219 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15081219 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15081219 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15081219 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15081219 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15081219 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15081219 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15081219 | pubmed:issn | 0168-3659 | lld:pubmed |
| pubmed-article:15081219 | pubmed:author | pubmed-author:MiFwu-LongFL | lld:pubmed |
| pubmed-article:15081219 | pubmed:author | pubmed-author:SungHsing-Wen... | lld:pubmed |
| pubmed-article:15081219 | pubmed:author | pubmed-author:LinYu-HsinYH | lld:pubmed |
| pubmed-article:15081219 | pubmed:author | pubmed-author:ChenSung-Chin... | lld:pubmed |
| pubmed-article:15081219 | pubmed:author | pubmed-author:WuYung-ChihYC | lld:pubmed |
| pubmed-article:15081219 | pubmed:author | pubmed-author:YuLin-ChienLC | lld:pubmed |
| pubmed-article:15081219 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15081219 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:15081219 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:15081219 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15081219 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15081219 | pubmed:pagination | 285-300 | lld:pubmed |
| pubmed-article:15081219 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:15081219 | pubmed:meshHeading | pubmed-meshheading:15081219... | lld:pubmed |
| pubmed-article:15081219 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15081219 | pubmed:articleTitle | A novel pH-sensitive hydrogel composed of N,O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery. | lld:pubmed |
| pubmed-article:15081219 | pubmed:affiliation | Department of Chemical Engineering, National Tsing Hua University, 101 Section 2, Kung-Fu Road, Hsinchu 30013, Taiwan, ROC. | lld:pubmed |
| pubmed-article:15081219 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15081219 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15081219 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
