Source:http://linkedlifedata.com/resource/pubmed/id/15080996
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
2004-4-14
|
| pubmed:abstractText |
Structural modifications of the aminopyridine P(1)(') group of imidazole acetic acid based TAFIa inhibitors led to the discovery of the aminocyclopentyl analog 28, a 1 nM TAFIa inhibitor with CLT(50) functional activity of 14 nM but without selectivity against CPB. While not as active, aminobutyl derivative 27 provided an improved 6.7-fold selectivity for TAFIa versus CPB.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0960-894X
|
| pubmed:author |
pubmed-author:BaileyCarolynC,
pubmed-author:BarrowJames CJC,
pubmed-author:BossermanMicheleM,
pubmed-author:CarrollStevenS,
pubmed-author:ColussiDennisD,
pubmed-author:LindsleyStacey RSR,
pubmed-author:MaoShi-ShanSS,
pubmed-author:McMastersDaniel RDR,
pubmed-author:NantermetPhilippe GPG,
pubmed-author:SelnickHarold GHG,
pubmed-author:VaccaJoseph PJP,
pubmed-author:YoungMaryBethM
|
| pubmed:issnType |
Print
|
| pubmed:day |
3
|
| pubmed:volume |
14
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2141-5
|
| pubmed:meshHeading | |
| pubmed:year |
2004
|
| pubmed:articleTitle |
Imidazole acetic acid TAFIa inhibitors: SAR studies centered around the basic P(1)(') group.
|
| pubmed:affiliation |
Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 4, West Point, PA 19486, USA. philippe_nantermet@merck.com
|
| pubmed:publicationType |
Journal Article
|