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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2004-4-14
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pubmed:abstractText |
DNA binding ligands with potent antimicrobial activity against Gram-positive bacteria were further optimized by variation of the internal aromatic amino acids. This modification led to compounds with improved in vivo efficacy in lethal murine models of peritonitis (methicillin-resistant S. aureus, MRSA) and lung infection (S. pneumoniae).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BürliRoland WRW,
pubmed-author:ChenAlfredA,
pubmed-author:DuanJian-XinJX,
pubmed-author:GeYigongY,
pubmed-author:GrossMatthewM,
pubmed-author:HuWenhaoW,
pubmed-author:IwamotoMariM,
pubmed-author:JiangVernonV,
pubmed-author:JohnsonKirk WKW,
pubmed-author:JonesPeterP,
pubmed-author:KaizermanJacob AJA,
pubmed-author:MoserHeinz EHE,
pubmed-author:StantonTimothyT,
pubmed-author:TouamiSofiaS,
pubmed-author:TruongKietK
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2067-72
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15080980-Amino Acids, Aromatic,
pubmed-meshheading:15080980-Animals,
pubmed-meshheading:15080980-Anti-Bacterial Agents,
pubmed-meshheading:15080980-DNA,
pubmed-meshheading:15080980-Disease Models, Animal,
pubmed-meshheading:15080980-Ligands,
pubmed-meshheading:15080980-Lung Diseases,
pubmed-meshheading:15080980-Mice,
pubmed-meshheading:15080980-Peritonitis,
pubmed-meshheading:15080980-Staphylococcal Infections,
pubmed-meshheading:15080980-Staphylococcus aureus,
pubmed-meshheading:15080980-Streptococcal Infections,
pubmed-meshheading:15080980-Streptococcus pneumoniae
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pubmed:year |
2004
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pubmed:articleTitle |
DNA binding ligands with in vivo efficacy in murine models of bacterial infection: optimization of internal aromatic amino acids.
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pubmed:affiliation |
Genesoft Pharmaceuticals, 7300 Shoreline Court, South San Francisco, CA 94080, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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