Linked Life Data

15080703

Source:http://linkedlifedata.com/resource/pubmed/id/15080703

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
2004-4-14
pubmed:abstractText
We report the synthesis and characterization of dirhodium tetracarboxylate complexes [Rh(2)(mu-O(2)CR)(4)(L)(2)], with R = Me and L = dansyl-imidazole (Ds-im) or dansyl-piperazine (Ds-pip). The fluorophores coordinate to the axial sites of the dirhodium core through the imidazole or piperazine N-atom and emit only weakly when excited at 365 or 345 nm for the Ds-im and Ds-pip complexes, respectively. These fluorophore-containing complexes were investigated for their ability to elicit a fluorescence response in the presence of NO. An immediate increase in fluorescence emission of greater than 15-fold occurs when NO is admitted to solutions containing [Rh(2)(mu-O(2)CMe)(4)] and Ds-pip or Ds-im. In both systems, the fluorescence response, which arises by NO-induced displacement of the axially coordinated fluorophore, is reversible with a sensitivity of approximately 4 microM. The related dinitrosyl complexes [Rh(2)(mu-O(2)CR)(4)(NO)(2)], where R = Me, Et, or n-Pr, were prepared, structurally characterized, and found to be air-stable, losing NO upon standing in solution. Sequestration of a methylene chloride solution of the Ds-pip complex from aqueous media by a NO-permeable membrane allows for fluorescence detection of NO for potential applications in biological fluids.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0002-7863
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
126
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4972-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Dirhodium tetracarboxylate scaffolds as reversible fluorescence-based nitric oxide sensors.
pubmed:affiliation
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.