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rdf:type |
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lifeskim:mentions |
umls-concept:C0020971,
umls-concept:C0032136,
umls-concept:C0178539,
umls-concept:C0314603,
umls-concept:C0679058,
umls-concept:C0871261,
umls-concept:C1547699,
umls-concept:C1565115,
umls-concept:C1627358,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2349975,
umls-concept:C2700640,
umls-concept:C2911692
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pubmed:issue |
4
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|
pubmed:dateCreated |
2004-4-13
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|
pubmed:abstractText |
Transfecting cells with plasmid DNA encoding the protein Bax causes programmed cell death (apoptosis) and results in the formation of cell fragments (apoptotic bodies). It has been known for some time that when dendritic cells phagocytose apoptotic bodies derived from tumor cells, an immune response to tumor antigens can be generated.
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pubmed:grant |
|
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1099-498X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
445-54
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15079819-Animals,
pubmed-meshheading:15079819-Antibody Formation,
pubmed-meshheading:15079819-Antigens,
pubmed-meshheading:15079819-Apoptosis,
pubmed-meshheading:15079819-Female,
pubmed-meshheading:15079819-Immunization,
pubmed-meshheading:15079819-Injections, Intradermal,
pubmed-meshheading:15079819-Luciferases,
pubmed-meshheading:15079819-Luminescent Proteins,
pubmed-meshheading:15079819-Male,
pubmed-meshheading:15079819-Mice,
pubmed-meshheading:15079819-Mice, Inbred BALB C,
pubmed-meshheading:15079819-Mice, Inbred Strains,
pubmed-meshheading:15079819-Plasmids,
pubmed-meshheading:15079819-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:15079819-Skin,
pubmed-meshheading:15079819-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:15079819-bcl-2-Associated X Protein
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pubmed:year |
2004
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pubmed:articleTitle |
Enhancement of both cellular and humoral responses to genetic immunization by co-administration of an antigen-expressing plasmid and a plasmid encoding the pro-apoptotic protein Bax.
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pubmed:affiliation |
Veterans Affairs Medical Center, Center for AIDS Research, and Department of Internal Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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