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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2004-4-12
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pubmed:abstractText |
Because articular chondrocytes reside in a hypoxic milieu, anaerobic glycolysis is central in generating ATP to support chondrocyte matrix synthesis and viability, with mitochondrial oxidative phosphorylation possibly providing physiologic reserve ATP generation. Nitric oxide (NO) potently suppresses mitochondrial oxidative phosphorylation. Because enhanced cartilage NO generation occurs in osteoarthritis (OA), we systematically tested for mitochondrial dysfunction in the pathogenesis of OA.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1216-25
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15077304-Adenosine Triphosphate,
pubmed-meshheading:15077304-Aging,
pubmed-meshheading:15077304-Animals,
pubmed-meshheading:15077304-Cells, Cultured,
pubmed-meshheading:15077304-Chondrocalcinosis,
pubmed-meshheading:15077304-Chondrocytes,
pubmed-meshheading:15077304-Disease Models, Animal,
pubmed-meshheading:15077304-Glycosaminoglycans,
pubmed-meshheading:15077304-Guinea Pigs,
pubmed-meshheading:15077304-Male,
pubmed-meshheading:15077304-Microscopy, Electron,
pubmed-meshheading:15077304-Mitochondria,
pubmed-meshheading:15077304-Nitric Oxide,
pubmed-meshheading:15077304-Osteoarthritis, Knee,
pubmed-meshheading:15077304-Phosphoric Diester Hydrolases,
pubmed-meshheading:15077304-Pyrophosphatases,
pubmed-meshheading:15077304-Transglutaminases
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pubmed:year |
2004
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pubmed:articleTitle |
Mediation of spontaneous knee osteoarthritis by progressive chondrocyte ATP depletion in Hartley guinea pigs.
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pubmed:affiliation |
Veterans Affairs Medical Center, and University of California, San Diego, 92161, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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