Source:http://linkedlifedata.com/resource/pubmed/id/15077132
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
2004-5-21
|
| pubmed:abstractText |
Summary:Hematological inherited diseases can be cured by hematopoietic stem cell transplantation (HSCT) from an human leukocyte antigen (HLA)-identical sibling donor (MSD), but the outcome of unrelated donors (URD) or haploidentical donors (HMD) has been a cause of concern. In all, 94 children affected with inherited diseases underwent HSCT at a single center using MSD (group A, n=31), URD (group B, n=23) or HMD (group C, n=40). There was no difference in the rate of engraftment or in the incidence of grades III-IV acute graft-versus-host disease (GVHD) between the groups. Survival rate was 80.6% in group A, 62.5% in group B and 47.5% in group C (P=0.023). In group B, survival rate was 73.7% in the subgroup with zero or one class I mismatch, and 25% in the subgroup with two or more class I mismatches (P=0.04). In group C, survival rate was 83.3% in the 9/10-identical subgroup, 64.3% in the seven or 8/10 subgroup, and 25% in the five or 6/10 subgroup (P=0.0007). Thus, engraftment, incidence of GVHD and survival are similar in recipients of grafts from MSD, URD with 0-1 class I-mismatch, or HMD with at least 7/10 HLA matches. The low success of HSCT using more disparate donors suggests reserving them for patients with very poor prognosis.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0268-3369
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| pubmed:author |
pubmed-author:BlancheSS,
pubmed-author:Caillat-ZucmanSS,
pubmed-author:CasanovaJ-LJL,
pubmed-author:Cavazzana-CalvoMM,
pubmed-author:Dal CortivoLL,
pubmed-author:FischerAA,
pubmed-author:GannagéMM,
pubmed-author:Hacein-Bey-AbinaSS,
pubmed-author:HaddadEE,
pubmed-author:JabadoNN,
pubmed-author:Le DeistFF
|
| pubmed:copyrightInfo |
Copyright 2004 Nature Publishing Group
|
| pubmed:issnType |
Print
|
| pubmed:volume |
33
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1089-95
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:15077132-Adolescent,
pubmed-meshheading:15077132-Child,
pubmed-meshheading:15077132-Child, Preschool,
pubmed-meshheading:15077132-Genetic Diseases, Inborn,
pubmed-meshheading:15077132-Genotype,
pubmed-meshheading:15077132-Graft Survival,
pubmed-meshheading:15077132-Graft vs Host Disease,
pubmed-meshheading:15077132-Haplotypes,
pubmed-meshheading:15077132-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:15077132-Histocompatibility,
pubmed-meshheading:15077132-Histocompatibility Testing,
pubmed-meshheading:15077132-Humans,
pubmed-meshheading:15077132-Infant,
pubmed-meshheading:15077132-Opportunistic Infections,
pubmed-meshheading:15077132-Survival Analysis,
pubmed-meshheading:15077132-Tissue Donors,
pubmed-meshheading:15077132-Transplantation, Homologous,
pubmed-meshheading:15077132-Transplantation, Isogeneic,
pubmed-meshheading:15077132-Treatment Outcome
|
| pubmed:year |
2004
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| pubmed:articleTitle |
Impact of HLA matching on outcome of hematopoietic stem cell transplantation in children with inherited diseases: a single-center comparative analysis of genoidentical, haploidentical or unrelated donors.
|
| pubmed:affiliation |
Laboratory of Immunology, Hopital Necker, Paris, France. caillat@necker.fr
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|