|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2004-4-12
|
|
pubmed:abstractText |
Mice deficient in the glial water channel aquaporin-4 (AQP4) show decreased cerebral edema and improved neurological outcome following water intoxication or ischemic challenge. In this report, we tested seizure susceptibility in AQP4 mice. AQP4 mice and wild-type controls were given the chemoconvulsant pentylenetetrazol (PTZ) and monitored for seizure activity. At 40 mg/kg PTZ, all wild-type mice exhibited seizure activity, whereas six of seven AQP4 mice did not exhibit seizure activity. At 50 mg/kg PTZ, both groups exhibited seizure activity; however, the latency to generalized (tonic-clonic) seizures was significantly lower in wild-type than AQP4 mice. These results suggest that glial water channels may modulate brain excitability and the initiation and generalization of seizure activity.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0959-4965
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
9
|
|
pubmed:volume |
15
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
259-62
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:15076748-Action Potentials,
pubmed-meshheading:15076748-Animals,
pubmed-meshheading:15076748-Aquaporin 4,
pubmed-meshheading:15076748-Aquaporins,
pubmed-meshheading:15076748-Brain,
pubmed-meshheading:15076748-Brain Edema,
pubmed-meshheading:15076748-Convulsants,
pubmed-meshheading:15076748-Disease Models, Animal,
pubmed-meshheading:15076748-Dose-Response Relationship, Drug,
pubmed-meshheading:15076748-Electroencephalography,
pubmed-meshheading:15076748-Epilepsy,
pubmed-meshheading:15076748-Genetic Predisposition to Disease,
pubmed-meshheading:15076748-Membrane Potentials,
pubmed-meshheading:15076748-Mice,
pubmed-meshheading:15076748-Mice, Knockout,
pubmed-meshheading:15076748-Neurons,
pubmed-meshheading:15076748-Pentylenetetrazole,
pubmed-meshheading:15076748-Reaction Time
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Increased seizure threshold in mice lacking aquaporin-4 water channels.
|
|
pubmed:affiliation |
Department of Neurological Surgery, University of California, 505 Parnassus Ave, Box 0112, San Francisco, CA 94143, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
