|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2004-4-12
|
|
pubmed:abstractText |
NaCl loading of Dahl salt-sensitive rats (DS) stimulates marinobufagenin (MBG), an alpha1 Na/K-ATPase (NKA) isoform ligand. Cardiac function depends on NKA, which is regulated in part by endogenous digitalis-like ligands. Our goal was to study whether changes occur in MBG and endogenous ouabain (EO) production during cardiac remodelling in hypertensive DS, and whether these are associated with changes in myocardial NKA isoforms and sensitivity to MBG and ouabain.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0263-6352
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
22
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
389-97
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:15076199-Animals,
pubmed-meshheading:15076199-Bufanolides,
pubmed-meshheading:15076199-Cardiac Output, Low,
pubmed-meshheading:15076199-Cardiomegaly,
pubmed-meshheading:15076199-Enzyme Inhibitors,
pubmed-meshheading:15076199-Hypertension,
pubmed-meshheading:15076199-Isoenzymes,
pubmed-meshheading:15076199-Ligands,
pubmed-meshheading:15076199-Male,
pubmed-meshheading:15076199-Ouabain,
pubmed-meshheading:15076199-Rats,
pubmed-meshheading:15076199-Rats, Inbred Dahl,
pubmed-meshheading:15076199-Sodium Chloride,
pubmed-meshheading:15076199-Sodium-Potassium-Exchanging ATPase
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Coordinated shifts in Na/K-ATPase isoforms and their endogenous ligands during cardiac hypertrophy and failure in NaCl-sensitive hypertension.
|
|
pubmed:affiliation |
Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Baltimore, Maryland 21224, USA. FedorovO@grc.nia.nih.gov
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
