Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-4-12
pubmed:abstractText
When the yeast Saccharomyces cerevisiae shifts from rapid growth on glucose to slow growth on ethanol, it undergoes profound changes in cellular metabolism, including the destruction of most of the translational machinery. We have examined the effect of this metabolic change, termed the diauxic shift, on the frequency of translational errors. Recoding sites are mRNA sequences that increase the frequency of translational errors, providing a convenient reporter of translational accuracy. We found that the diauxic shift causes no overall change in translational accuracy but does cause a strong reduction in the frequency of one type of programmed error: Ty +1 frameshifting. Genetic data suggest that this effect may be due to changes in the relative amounts of tRNA participating in translation elongation. We discuss possible implications for expression strategies that use recoding.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-10542411, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-10592250, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-10635325, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-10917592, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-11080168, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-11233984, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-11249196, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-11574691, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-11596922, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-1182215, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-11943544, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-1482115, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-1515416, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-1547945, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-1561104, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-2010914, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-2164889, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-3072707, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-3736654, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-3963992, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-4530290, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-6391914, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-7515462, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-7636469, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-7650736, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-7784210, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-7813017, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-8083172, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-8171019, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-8196765, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-8203157, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-8243996, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-8267715, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-8730858, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-8852897, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-8913297, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-9115369, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-9159473, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-9381177, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-9382847, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-9388772, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-942051, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-9467951, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-9468314, http://linkedlifedata.com/resource/pubmed/commentcorrection/15075263-9531534
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1535-9778
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
331-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Translational accuracy during exponential, postdiauxic, and stationary growth phases in Saccharomyces cerevisiae.
pubmed:affiliation
Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland 21250, USA. stahl@infobiogen.fr
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.