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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2004-4-12
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pubmed:abstractText |
A combination of 8-methoxypsoralen and ultraviolet-A radiation (PUVA) is used for the treatment of T cell-mediated disorders, including chronic graft-versus-host disease. The mechanisms of action of this therapy, referred to as extracorporeal phototherapy, have not been fully elucidated. PUVA is known to induce apoptosis in T lymphocytes collected by apheresis, however scarce information is available concerning the apoptotic pathways activated by PUVA.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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|
pubmed:issn |
1592-8721
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
471-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15075081-Apoptosis,
pubmed-meshheading:15075081-Caspase 8,
pubmed-meshheading:15075081-Caspase 9,
pubmed-meshheading:15075081-Caspases,
pubmed-meshheading:15075081-Enzyme Activation,
pubmed-meshheading:15075081-Humans,
pubmed-meshheading:15075081-Jurkat Cells,
pubmed-meshheading:15075081-Leukemia, T-Cell,
pubmed-meshheading:15075081-Methoxsalen,
pubmed-meshheading:15075081-T-Lymphocytes,
pubmed-meshheading:15075081-Ultraviolet Therapy
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pubmed:year |
2004
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|
pubmed:articleTitle |
Caspase-9 is the upstream caspase activated by 8-methoxypsoralen and ultraviolet-A radiation treatment of Jurkat T leukemia cells and normal T lymphocytes.
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pubmed:affiliation |
Dipartimento di Scienze Anatomiche Umane e Fisiopatologia dell'Apparato Locomotore, Sezione di Anatomia, Cell Signaling Laboratory, Università di Bologna, via Irnerio 48, 40126 Bologna, Italy. amartell@biocfarm.unibo.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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