Linked Life Data

15072985

Source:http://linkedlifedata.com/resource/pubmed/id/15072985

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2004-4-9
pubmed:abstractText
This study investigated the determinants of sex-specific maximally attained levels of FEV(1), VC, and the ratio of FEV(1) to VC. Subjects were between the ages of 15 and 35 years (1,818 males and 1,732 females), participating in the Vlagtwedde/Vlaardingen study in The Netherlands. The subjects were followed (3-year intervals) with questionnaire, spirometry, peripheral blood eosinophil counts, and testing for airway responsiveness to histamine. Skin tests were performed only at study onset. Regression splines were used to assess the effects of these variables on levels of FEV(1), VC, and the ratio of FEV(1) to VC, with adjustment for age, height, and area of residence. Current (-44 ml/pack/day) and cumulative (-85 ml/10 packs/year) cigarette smoking were significant predictors of reduced maximal level of FEV(1) in males but not in females. The presence of respiratory symptoms (-114 ml in males, -106 ml in females), increased eosinophils (-128 ml [males], -53 ml [females]), and increased airway responsiveness (-225 ml [males], -213 ml [females]) were all significant predictors of reduced level of FEV(1). To the degree that these factors diminished plateau phase pulmonary function, they may be important predictors of chronic obstructive pulmonary disease in later life.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1073-449X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
169
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
941-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Determinants of maximally attained level of pulmonary function.
pubmed:affiliation
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't