Linked Life Data

15072717

Source:http://linkedlifedata.com/resource/pubmed/id/15072717

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-4-9
pubmed:abstractText
The generation of reactive oxygen species is typically associated with hyperoxia and ischemia reperfusion. Recent evidence has suggested that increased oxidative stress may occur with hypoxia. We hypothesized that oxidative stress would be increased in subjects exposed to high altitude hypoxia. We studied 28 control subjects living in Lima, Peru (sea level), at baseline and following 48 h exposure to high altitude (4300 m). To assess the effects of chronic altitude exposure, we studied 25 adult males resident in Cerro de Pasco, Peru (altitude 4300 m). We also studied 27 subjects living in Cerro de Pasco who develop excessive erythrocytosis (hematocrit > 65%) and chronic mountain sickness. Acute high altitude exposure led to increased urinary F(2)-isoprostane, 8-iso PGF(2 alpha) (1.31 +/- 0.8 microg/g creatinine versus 2.15 +/- 1.1, p = 0.001) and plasma total glutathione (1.29 +/- 0.10 micromol versus 1.37 +/- 0.09, p = 0.002), with a trend to increased plasma thiobarbituric acid reactive substance (TBARS) (59.7 +/- 36 pmol/mg protein versus 63.8 +/- 27, p = NS). High altitude residents had significantly elevated levels of urinary 8-iso PGF(2 alpha) (1.3 +/- 0.8 microg/g creatinine versus 4.1 +/- 3.4, p = 0.007), plasma TBARS (59.7 +/- 36 pmol/mg protein versus 85 +/- 28, p = 0.008), and plasma total glutathione (1.29 +/- 0.10 micromol versus 1.55 +/- 0.19, p < 0.0001) compared to sea level. High altitude residents with excessive erythrocytosis had higher levels of oxidative stress compared to high altitude residents with normal hematological adaptation. In conclusion, oxidative stress is increased following both acute exposure to high altitude without exercise and with chronic residence at high altitude.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1527-0297
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
61-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:15072717-Acclimatization, pubmed-meshheading:15072717-Acute Disease, pubmed-meshheading:15072717-Adult, pubmed-meshheading:15072717-Altitude, pubmed-meshheading:15072717-Altitude Sickness, pubmed-meshheading:15072717-Chronic Disease, pubmed-meshheading:15072717-Dinoprostone, pubmed-meshheading:15072717-F2-Isoprostanes, pubmed-meshheading:15072717-Glutathione, pubmed-meshheading:15072717-Hemodynamics, pubmed-meshheading:15072717-Humans, pubmed-meshheading:15072717-Hypertension, Pulmonary, pubmed-meshheading:15072717-Isoprostanes, pubmed-meshheading:15072717-Lipid Peroxidation, pubmed-meshheading:15072717-Male, pubmed-meshheading:15072717-Middle Aged, pubmed-meshheading:15072717-Oxidative Stress, pubmed-meshheading:15072717-Peru, pubmed-meshheading:15072717-Polycythemia, pubmed-meshheading:15072717-Risk Factors, pubmed-meshheading:15072717-Thiobarbituric Acid Reactive Substances, pubmed-meshheading:15072717-Ventricular Dysfunction, Right
pubmed:year
2004
pubmed:articleTitle
Increased oxidative stress following acute and chronic high altitude exposure.
pubmed:affiliation
University of Washington, Division of Nephrology, Seattle, WA 98195, USA. jashleyj@u.washington.edu
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Research Support, Non-U.S. Gov't