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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-4-9
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pubmed:abstractText |
The thymus contains many apoptotic cells that arise from the process of positive and negative selection. Both thymic macrophages and thymic nurse cells/nursing thymic epithelial cells (nursing TECs), non-professional phagocytes, recognize and ingest apoptotic cells without inflammation or tissue damage. Previously we reported that human scavenger receptor class B (SR-B1) is involved in recognition of apoptotic thymocytes by nursing TECs. In this study, we examined the expression and role of a phosphatidylserine receptor (PSR). This receptor is believed to participate in the clearance of apoptotic cells. PSR was strongly expressed in nursing TECs. Transforming growth factor-beta augmented the expression of PSR leading to enhanced binding of apoptotic cells to nursing TECs. In nursing TECs, suppressed expression of human SR-B1 with anti-PSR antibody decreased binding of apoptotic thymocytes to nursing TECs. Our results suggest that both PSR and SR-B1 are expressed in nursing TECs and these receptors appear to play a major role in the clearance of apoptotic cells from the thymus.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/JMJD6 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Jumonji Domain-Containing Histone...,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/Ptdsr protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Lipoprotein,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Scavenger,
http://linkedlifedata.com/resource/pubmed/chemical/SCARB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Scavenger Receptors, Class B,
http://linkedlifedata.com/resource/pubmed/chemical/high density lipoprotein receptors,
http://linkedlifedata.com/resource/pubmed/chemical/phosphatidylserine receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0952-5041
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
497-505
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15072554-Animals,
pubmed-meshheading:15072554-Apoptosis,
pubmed-meshheading:15072554-Cells, Cultured,
pubmed-meshheading:15072554-Cytokines,
pubmed-meshheading:15072554-Epithelial Cells,
pubmed-meshheading:15072554-Female,
pubmed-meshheading:15072554-Humans,
pubmed-meshheading:15072554-Jumonji Domain-Containing Histone Demethylases,
pubmed-meshheading:15072554-Lipoproteins, HDL,
pubmed-meshheading:15072554-Mice,
pubmed-meshheading:15072554-Mice, Inbred BALB C,
pubmed-meshheading:15072554-Oligonucleotides, Antisense,
pubmed-meshheading:15072554-Receptors, Cell Surface,
pubmed-meshheading:15072554-Receptors, Immunologic,
pubmed-meshheading:15072554-Receptors, Lipoprotein,
pubmed-meshheading:15072554-Receptors, Scavenger,
pubmed-meshheading:15072554-Scavenger Receptors, Class B,
pubmed-meshheading:15072554-Thymus Gland
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pubmed:year |
2004
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pubmed:articleTitle |
Phosphatidylserine receptor cooperates with high-density lipoprotein receptor in recognition of apoptotic cells by thymic nurse cells.
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pubmed:affiliation |
First Department of Internal Medicine, Kagawa Medical University, Kagawa 761-0793, Japan.
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pubmed:publicationType |
Journal Article
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