|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001483,
umls-concept:C0001688,
umls-concept:C0017296,
umls-concept:C0025932,
umls-concept:C0205195,
umls-concept:C0206558,
umls-concept:C0520484,
umls-concept:C0851346,
umls-concept:C0879626,
umls-concept:C1336633,
umls-concept:C1407029,
umls-concept:C1522656,
umls-concept:C1704419
|
|
pubmed:issue |
1-2
|
|
pubmed:dateCreated |
2004-4-9
|
|
pubmed:abstractText |
In mouse models of prostate and breast cancer therapeutic effects are enhanced when adenoviral HSV TK gene therapy is combined with ionizing radiation. In the present study, we adopted this approach for the treatment of human glioblastoma xenografts in an athymic mouse model and assessed treatment results as well as toxic side effects.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0167-594X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
67
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
177-88
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:15072465-Animals,
pubmed-meshheading:15072465-Antiviral Agents,
pubmed-meshheading:15072465-Cell Line, Tumor,
pubmed-meshheading:15072465-Combined Modality Therapy,
pubmed-meshheading:15072465-Female,
pubmed-meshheading:15072465-Ganciclovir,
pubmed-meshheading:15072465-Gene Therapy,
pubmed-meshheading:15072465-Glioblastoma,
pubmed-meshheading:15072465-Humans,
pubmed-meshheading:15072465-Immunohistochemistry,
pubmed-meshheading:15072465-Mice,
pubmed-meshheading:15072465-Mice, Nude,
pubmed-meshheading:15072465-Radiotherapy,
pubmed-meshheading:15072465-Simplexvirus,
pubmed-meshheading:15072465-Thymidine Kinase,
pubmed-meshheading:15072465-Transplantation, Heterologous
|
|
pubmed:articleTitle |
The combination of adenoviral HSV TK gene therapy and radiation is effective in athymic mouse glioblastoma xenografts without increasing toxic side effects.
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|
pubmed:affiliation |
Molecular Neuro-Oncology Laboratory, Department of Radiation Oncology, Massachusetts General Hospital East, Charlestown, MA, USA. ulf.nestler@neuro.med.uni-giessen.de
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|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
