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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
2004-4-13
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pubmed:abstractText |
Transient (low-conductance) opening of the mitochondrial permeability transition pore (mPTP) may limit mitochondrial calcium load and mediate mitochondrial reactive oxygen species (ROS) signaling. We hypothesize that transient mPTP opening and ROS mediate the protection associated with myocardial preconditioning and mitochondrial uncoupling.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2,4-Dinitrophenol,
http://linkedlifedata.com/resource/pubmed/chemical/2-chloro-N(6)cyclopentyladenosine,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-1 Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Cardiotonic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Diazoxide,
http://linkedlifedata.com/resource/pubmed/chemical/Ion Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Lactones,
http://linkedlifedata.com/resource/pubmed/chemical/Macromolecular Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial Membrane Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Spiro Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Uncoupling Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents,
http://linkedlifedata.com/resource/pubmed/chemical/mitochondrial permeability...,
http://linkedlifedata.com/resource/pubmed/chemical/sanglifehrin A
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
13
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pubmed:volume |
109
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1714-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15066952-2,4-Dinitrophenol,
pubmed-meshheading:15066952-Adenosine,
pubmed-meshheading:15066952-Adrenergic alpha-1 Receptor Agonists,
pubmed-meshheading:15066952-Adrenergic alpha-Agonists,
pubmed-meshheading:15066952-Animals,
pubmed-meshheading:15066952-Cardiotonic Agents,
pubmed-meshheading:15066952-Cells, Cultured,
pubmed-meshheading:15066952-Cyclosporine,
pubmed-meshheading:15066952-Diazoxide,
pubmed-meshheading:15066952-Electric Conductivity,
pubmed-meshheading:15066952-Ion Channel Gating,
pubmed-meshheading:15066952-Ion Channels,
pubmed-meshheading:15066952-Ion Transport,
pubmed-meshheading:15066952-Ischemic Preconditioning, Myocardial,
pubmed-meshheading:15066952-Lactones,
pubmed-meshheading:15066952-Macromolecular Substances,
pubmed-meshheading:15066952-Male,
pubmed-meshheading:15066952-Mitochondria, Heart,
pubmed-meshheading:15066952-Mitochondrial Membrane Transport Proteins,
pubmed-meshheading:15066952-Myocardial Ischemia,
pubmed-meshheading:15066952-Myocardial Reperfusion Injury,
pubmed-meshheading:15066952-Myocytes, Cardiac,
pubmed-meshheading:15066952-Oxidative Phosphorylation,
pubmed-meshheading:15066952-Rats,
pubmed-meshheading:15066952-Rats, Sprague-Dawley,
pubmed-meshheading:15066952-Reactive Oxygen Species,
pubmed-meshheading:15066952-Signal Transduction,
pubmed-meshheading:15066952-Spiro Compounds,
pubmed-meshheading:15066952-Uncoupling Agents,
pubmed-meshheading:15066952-Vasodilator Agents
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pubmed:year |
2004
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pubmed:articleTitle |
Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection.
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pubmed:affiliation |
The Hatter Institute and Centre for Cardiology, University College London, UK.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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