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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-4-6
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pubmed:abstractText |
Drosophila olfactory receptor neurons (ORNs) elaborate a precise internal representation of the external olfactory world in the antennal lobe (AL), a structure analagous to the vertebrate olfactory bulb. ORNs expressing the same odorant receptor innervate common targets in a highly organized neuropilar structure inside the AL, the glomerulus. During normal development, ORNs target to specific regions of the AL and segregate into subclass-specific aggregates called protoglomeruli prior to extensive intermingling with target dendrites to form mature glomeruli. Using a panel of ORN subclass-specific markers, we demonstrate that in the adult AL, N-cadherin (N-cad) mutant ORN terminals remain segregated from dendrites of target neurons. N-cad plays a crucial role in protoglomerulus formation but is largely dispensible for targeting to the appropriate region of the AL. We propose that N-cad, a homophilic cell adhesion molecule, acts in a permissive fashion to promote subclass-specific sorting of ORN axon terminals into protoglomeruli.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0896-6273
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
77-88
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15066266-Animals,
pubmed-meshheading:15066266-Animals, Genetically Modified,
pubmed-meshheading:15066266-Brain,
pubmed-meshheading:15066266-Cadherins,
pubmed-meshheading:15066266-Dendrites,
pubmed-meshheading:15066266-Drosophila,
pubmed-meshheading:15066266-Fluorescent Antibody Technique,
pubmed-meshheading:15066266-Gene Expression Regulation, Developmental,
pubmed-meshheading:15066266-Genetic Techniques,
pubmed-meshheading:15066266-Green Fluorescent Proteins,
pubmed-meshheading:15066266-Hu Paraneoplastic Encephalomyelitis Antigens,
pubmed-meshheading:15066266-Luminescent Proteins,
pubmed-meshheading:15066266-Membrane Proteins,
pubmed-meshheading:15066266-Mutation,
pubmed-meshheading:15066266-Olfactory Bulb,
pubmed-meshheading:15066266-Olfactory Pathways,
pubmed-meshheading:15066266-Olfactory Receptor Neurons,
pubmed-meshheading:15066266-Presynaptic Terminals,
pubmed-meshheading:15066266-R-SNARE Proteins,
pubmed-meshheading:15066266-Ribonucleoproteins
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pubmed:year |
2004
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pubmed:articleTitle |
Afferent induction of olfactory glomeruli requires N-cadherin.
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pubmed:affiliation |
Howard Hughes Medical Institute, Department of Biological Chemistry, Geffen School of Medicine, Molecular Biology Institute, Box 951662, University of California, Los Angeles, Los Angeles, CA 90095, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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