Source:http://linkedlifedata.com/resource/pubmed/id/15065150
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rdf:type | |
lifeskim:mentions |
umls-concept:C0021107,
umls-concept:C0026336,
umls-concept:C0038257,
umls-concept:C0043240,
umls-concept:C0086661,
umls-concept:C0205179,
umls-concept:C0205197,
umls-concept:C0332281,
umls-concept:C0392756,
umls-concept:C0948480,
umls-concept:C1135183,
umls-concept:C1450425,
umls-concept:C1522492,
umls-concept:C1801960
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pubmed:issue |
4
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pubmed:dateCreated |
2004-4-5
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pubmed:abstractText |
An advanced six-ring morpholino backbone c-myc antisense (AVI-4126) was shown to inhibit c-myc expression and intimal hyperplasia after local catheter delivery in a porcine balloon injury model. The purpose of this study was to investigate the effects of an AVI-4126-eluting phosphorylcholine-coated (PC) stent on c-myc expression restenosis and vascular healing after stent implantation in porcine coronary arteries. PC stents were loaded with AVI-4126 using soak trap. Nine pigs underwent AVI-4126 PC coronary stent implantation (two stents/animal). Two to six hours postprocedure, three pigs were sacrificed and stented segments were analyzed by Western blot for c-myc expression. In chronic experiments, six pigs (12 stent sites) were sacrificed at 28 days following intervention and vessels were perfusion-fixed. High-performance liquid chromatography analysis of plasma samples showed minimal presence of the antisense. Western blot analysis of the stented vessels demonstrated inhibition of c-myc expression at 2 and 6 hr after procedure. Quantitative histologic morphometry showed that the neointimal area was significantly reduced (by 40%) in the antisense-coated group compared with control (2.3 +/- 0.7 vs. 3.9 +/- 0.8 mm(2), respectively; P = 0.0077). Immunostaining and electron microscopy demonstrated complete endothelialization, without fibrin deposition, thrombosis, or necrosis in all implanted stents. In the porcine coronary model, an advanced c-myc-eluting PC stent blocked c-myc expression and significantly inhibited myointimal hyperplasia and allowed complete reendothelialization and healing response.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Coated Materials, Biocompatible,
http://linkedlifedata.com/resource/pubmed/chemical/Morpholines,
http://linkedlifedata.com/resource/pubmed/chemical/Morpholinos,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphorylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-myc
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1522-1946
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pubmed:author |
pubmed-author:DangasGeorgeG,
pubmed-author:IversenPatrickP,
pubmed-author:IyerSriramS,
pubmed-author:KimHan-SooHS,
pubmed-author:KipshidzeNicholas NNN,
pubmed-author:LeonMartin BMB,
pubmed-author:MehranRoxanaR,
pubmed-author:MosesJeffrey WJW,
pubmed-author:NewGishelG,
pubmed-author:RoubinGary SGS,
pubmed-author:SeabornRufusR,
pubmed-author:StoneGregg WGW,
pubmed-author:TioFerminF,
pubmed-author:TsapenkoMykolaM,
pubmed-author:WaksmanRonR,
pubmed-author:YiazdiHamidH
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pubmed:copyrightInfo |
Copyright 2004 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
518-27
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15065150-Animals,
pubmed-meshheading:15065150-Blood Vessel Prosthesis Implantation,
pubmed-meshheading:15065150-Coated Materials, Biocompatible,
pubmed-meshheading:15065150-Coronary Angiography,
pubmed-meshheading:15065150-Coronary Restenosis,
pubmed-meshheading:15065150-Coronary Vessels,
pubmed-meshheading:15065150-Disease Models, Animal,
pubmed-meshheading:15065150-Female,
pubmed-meshheading:15065150-Follow-Up Studies,
pubmed-meshheading:15065150-Male,
pubmed-meshheading:15065150-Models, Cardiovascular,
pubmed-meshheading:15065150-Morpholines,
pubmed-meshheading:15065150-Morpholinos,
pubmed-meshheading:15065150-Phosphorylcholine,
pubmed-meshheading:15065150-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:15065150-Statistics as Topic,
pubmed-meshheading:15065150-Stents,
pubmed-meshheading:15065150-Swine,
pubmed-meshheading:15065150-Treatment Outcome,
pubmed-meshheading:15065150-Tunica Intima
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pubmed:year |
2004
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pubmed:articleTitle |
Advanced c-myc antisense (AVI-4126)-eluting phosphorylcholine-coated stent implantation is associated with complete vascular healing and reduced neointimal formation in the porcine coronary restenosis model.
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pubmed:affiliation |
Lenox Hill Heart and Vascular Institute and Cardiovascular Research Foundation, New York, New York 10021, USA. nkipshidze@lenoxhill.net
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Evaluation Studies
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