Linked Life Data

15061260

Source:http://linkedlifedata.com/resource/pubmed/id/15061260

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-4-5
pubmed:abstractText
To clarify the biological significance of [18F]fluorodeoxyglucose (18F-FDG) accumulation in patients with cancer, we assessed the relationships between 18F-FDG uptake and glucose transporter-1 (GLUT-1) expression and proliferation rate in human glioma and lung cancer. We obtained FDG PET images and measured standardized uptake values (SUVs) of primary tumours in 13 patients with brain glioma and 25 patients with non-small-cell lung cancer. After surgery, portions of respected tumours were obtained, and the proliferation rate was measured as proliferation index (per cent of (S+G2+M)/(G0+G1+S+G2+M)) using DNA flow cytometry. The expression of GLUT-1 in a tumour was evaluated by using immunostaining. We classified GLUT-1 expression as grade 0 (no positive cell), grade 1 (< 10% cells positive), grade 2 (11-50% cells positive) and grade 3 (51-100% cells positive). Based on the expression of GLUT-1, cases with grades 0, 1, 2 and 3 showed SUVs of 6.1 +/- 2.8, 5.0 +/- 3.2, 8.3 +/- 3.3 and 10.4 +/- 6.6, respectively (P < 0.05). Non-small-cell lung cancer showed higher FDG uptake (SUV, 8.5 +/- 5.1) and higher GLUT-1 expression (grade, 2.0 +/- 1.0) than did brain glioma (SUV, 4.7 +/- 2.5; grade, 0.8 +/- 0.8). Based on the total number of cases, SUVs did not relate to proliferation index (r = 0.19). In non-small-cell lung cancer, SUVs did not correlate with proliferation index, whereas in glioma, SUVs were strongly related to proliferation index (r = 0.79, P < 0.01). In conclusion, FDG uptake generally correlated with GLUT-1 expression in non-small-cell lung cancer and glioma. In the case of glioma, FDG uptake also indicated increased cellular proliferation, which was not demonstrated in non-small-cell lung cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0143-3636
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
11-7
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:15061260-Brain Neoplasms, pubmed-meshheading:15061260-Carcinoma, Non-Small-Cell Lung, pubmed-meshheading:15061260-Cell Division, pubmed-meshheading:15061260-Female, pubmed-meshheading:15061260-Fluorodeoxyglucose F18, pubmed-meshheading:15061260-Gene Expression Regulation, Neoplastic, pubmed-meshheading:15061260-Glioma, pubmed-meshheading:15061260-Glucose Transporter Type 1, pubmed-meshheading:15061260-Humans, pubmed-meshheading:15061260-Lung Neoplasms, pubmed-meshheading:15061260-Male, pubmed-meshheading:15061260-Middle Aged, pubmed-meshheading:15061260-Monosaccharide Transport Proteins, pubmed-meshheading:15061260-Radiopharmaceuticals, pubmed-meshheading:15061260-Reproducibility of Results, pubmed-meshheading:15061260-Sensitivity and Specificity, pubmed-meshheading:15061260-Statistics as Topic, pubmed-meshheading:15061260-Tumor Markers, Biological
pubmed:year
2004
pubmed:articleTitle
Comparison of [18F]fluorodeoxyglucose uptake with glucose transporter-1 expression and proliferation rate in human glioma and non-small-cell lung cancer.
pubmed:affiliation
Department of Nuclear Medicine, Seoul National University College of Medicine, Korea. jkchung@plaza.snu.ac.kr
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Validation Studies