Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6982
pubmed:dateCreated
2004-4-1
pubmed:abstractText
The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine and drug development, having made inestimable contributions to human health. We report here the genome sequence of the Brown Norway (BN) rat strain. The sequence represents a high-quality 'draft' covering over 90% of the genome. The BN rat sequence is the third complete mammalian genome to be deciphered, and three-way comparisons with the human and mouse genomes resolve details of mammalian evolution. This first comprehensive analysis includes genes and proteins and their relation to human disease, repeated sequences, comparative genome-wide studies of mammalian orthologous chromosomal regions and rearrangement breakpoints, reconstruction of ancestral karyotypes and the events leading to existing species, rates of variation, and lineage-specific and lineage-independent evolutionary events such as expansion of gene families, orthology relations and protein evolution.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1476-4687
pubmed:author
pubmed-author:DoiMM, pubmed-author:HORNAA, pubmed-author:POYR KRK, pubmed-author:CooneyA JAJ, pubmed-author:FaziSS, pubmed-author:Mar AlbàMM, pubmed-author:CollinsFrancisF, pubmed-author:EichlerEvan EEE, pubmed-author:BaileyJeffrey AJA, pubmed-author:BorkPeerP, pubmed-author:PachterLiorL, pubmed-author:TwiggerSimonS, pubmed-author:PaskoDeanD, pubmed-author:TonellatoPeter JPJ, pubmed-author:GoodstadtLeoL, pubmed-author:CopleyRichard RRR, pubmed-author:PontingChris PCP, pubmed-author:BirneyEwanE, pubmed-author:DurbinRichardR, pubmed-author:ZhangZhengdongZ, pubmed-author:TraskBarbara JBJ, pubmed-author:GreenEric DED, pubmed-author:ZhangYiY, pubmed-author:JacobHoward JHJ, pubmed-author:LehrachHansH, pubmed-author:OsoegawaKazutoyoK, pubmed-author:ElnitskiLauraL, pubmed-author:SchwartzScottS, pubmed-author:BlakesleyRobert WRW, pubmed-author:BouffardGerard GGG, pubmed-author:MillerWebbW, pubmed-author:BourqueGuillaumeG, pubmed-author:PevznerPavel APA, pubmed-author:SmitArianA, pubmed-author:BatzoglouSerafimS, pubmed-author:NekrutenkoAntonA, pubmed-author:GantenDetlevD, pubmed-author:ChenRuiR, pubmed-author:WuJia QianJQ, pubmed-author:TaylorJamesJ, pubmed-author:RubinEdward MEM, pubmed-author:GrahamScottS, pubmed-author:TaylorMartin SMS, pubmed-author:KwitekAnne EAE, pubmed-author:FraserClaire MCM, pubmed-author:VenterJ CraigJC, pubmed-author:LindpaintnerKlausK, pubmed-author:HausslerDavidD, pubmed-author:López-OtínCarlosC, pubmed-author:HardisonRoss CRC, pubmed-author:RiemerCathyC, pubmed-author:PayseurBret ABA, pubmed-author:ChiaromonteFrancescaF, pubmed-author:D'SouzaLisa MLM, pubmed-author:WeinstockGeorge MGM, pubmed-author:YoungJanet MJM, pubmed-author:GibbsRichard ARA, pubmed-author:StoneEric AEA, pubmed-author:SidowArendA, pubmed-author:HübnerNorbertN, pubmed-author:LiuYueY, pubmed-author:SuttonGranger GGG, pubmed-author:AdamsMark DMD, pubmed-author:HimmelbauerHeinzH, pubmed-author:OkwuonuGeoffreyG, pubmed-author:DelgadoOliverO, pubmed-author:MuznyDonna MDM, pubmed-author:MetzkerMichael LML, pubmed-author:CooperDavid NDN, pubmed-author:PuenteXose SXS, pubmed-author:HuangHuiH, pubmed-author:TeslerGlennG, pubmed-author:GuZhipingZ, pubmed-author:McPhersonJohnJ, pubmed-author:DubchakInnaI, pubmed-author:CooperGregory MGM, pubmed-author:AlexanderssonMarinaM
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