|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1992-9-21
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
A gene encoding high-level resistance to ethidium bromide (EB) and antiseptics was isolated from a transferable plasmid, pTZ22, in Staphylococcus aureus. DNA sequencing revealed that the plasmid has two copies of the ebr gene that normally mediates low-level resistance to EB and antiseptics. The efflux rate for EB of strains with duplicated ebr genes was twice the rate of strains with a single ebr gene. It was concluded that the duplication of ebr is responsible for the high-level resistance to EB and antiseptics.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0378-1097
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
72
|
|
pubmed:geneSymbol |
ebr
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
109-13
|
|
pubmed:dateRevised |
2006-5-1
|
|
pubmed:meshHeading |
pubmed-meshheading:1505735-Amino Acid Sequence,
pubmed-meshheading:1505735-Anti-Infective Agents, Local,
pubmed-meshheading:1505735-Base Sequence,
pubmed-meshheading:1505735-Chromosome Deletion,
pubmed-meshheading:1505735-Chromosomes, Bacterial,
pubmed-meshheading:1505735-Drug Resistance, Microbial,
pubmed-meshheading:1505735-Ethidium,
pubmed-meshheading:1505735-Molecular Sequence Data,
pubmed-meshheading:1505735-Plasmids,
pubmed-meshheading:1505735-Staphylococcus aureus
|
|
pubmed:year |
1992
|
|
pubmed:articleTitle |
High-level resistance to ethidium bromide and antiseptics in Staphylococcus aureus.
|
|
pubmed:affiliation |
Department of Microbiology, Tokyo College of Pharmacy, Japan.
|
|
pubmed:publicationType |
Journal Article
|
