Linked Life Data

15056766

Source:http://linkedlifedata.com/resource/pubmed/id/15056766

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-4-1
pubmed:abstractText
The gonadotrophin-releasing hormone (GnRH) system in female Damaraland mole-rats, Cryptomys damarensis, has been investigated to map the distribution of GnRH-immunoreactive (GnRH-IR) structures in the brain of this species and to assess whether changes in this system may mediate the inhibitory effect of social cues on fertility. The distribution of GnRH-IR cell bodies and fibres was similar to that of other mammals, forming a loose continuum along a septo-preoptico-infundibular pathway. GnRH-IR cell bodies were more abundant in the vicinity of the organum vasculosum of the lamina terminalis than in the medial basal hypothalamus. GnRH-IR cells and fibres were also found in the subfornical organ. The cell bodies were typically unipolar or bipolar. No differences were found in the morphology or size of the cell bodies or in the number of cells between non-reproductive females and reproductive females living together in a colony. However, GnRH concentrations, measured in the brain by radioimmunoassay, were significantly higher in non-reproductive females than in reproductive females; this finding was complemented by the reduced immunoreactivity for GnRH in the median eminence and proximal pituitary stalk of reproductive females. In contrast, the concentrations of GnRH measured by radioimmunoassay in non-reproductive and reproductive males did not differ. These results are consistent with the hypothesis that GnRH release is inhibited in the non-reproductive females but not in the non-reproductive males of this species.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1470-1626
pubmed:author
pubmed:issnType
Print
pubmed:volume
127
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
13-21
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
A neuroanatomical and neuroendocrinological study into the relationship between social status and the GnRH system in cooperatively breeding female Damaraland mole-rats, Cryptomys damarensis.
pubmed:affiliation
Department of Zoology and Entomology, University of Pretoria, Pretoria, South Africa.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't