Linked Life Data

15055299

Source:http://linkedlifedata.com/resource/pubmed/id/15055299

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
157
pubmed:dateCreated
2004-4-1
pubmed:abstractText
This chapter will review a variety of issues related to the use of biomarkers in molecular epidemiological studies. It will draw upon experience gained from related mechanistic research in toxicological studies. This includes important methodological issues that impact on the type of assays that can be used and how these issues affect the selection of the method and the biological sample. It will also address issues affecting the use of biomarkers as measures of exposure and effect, and discuss inferences for causality and the selection of target organ versus surrogate tissues. Combining information from toxicological studies can also aid in the interpretation of epidemiological studies, such as tissues with and without strong biological plausibility and relationships between observed DNA adducts and those that arise from endogenous processes. Finally, it will discuss issues related to important pathways of metabolism and implications of genetic polymorphisms. These critical issues affect both the design and interpretation of molecular epidemiological studies.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-5038
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
237-46
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Toxicological considerations in the application and interpretation of DNA adducts in epidemiological studies.
pubmed:affiliation
School of Medicine, University of North Carolina, Chapel Hill 27599-7525, USA. jswenber@sph.unc.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review