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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2004-3-30
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pubmed:abstractText |
The extracellular signal-regulated kinase pathway of the mitogen-activated protein kinase signal transduction cascade has been implicated in the neuronal and endothelial dysfunction witnessed following cerebral ischemia-reperfusion injury. Extracellular signal-regulated kinase is activated by mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2. We evaluated the ability of a mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2-specific inhibitor (U0126) to block extracellular signal-regulated kinase activation and mitigate ischemic neuronal damage in a model of deep hypothermic circulatory arrest.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-5223
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
127
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1033-40
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15052200-Animals,
pubmed-meshheading:15052200-Animals, Newborn,
pubmed-meshheading:15052200-Brain Ischemia,
pubmed-meshheading:15052200-Butadienes,
pubmed-meshheading:15052200-Cardiopulmonary Bypass,
pubmed-meshheading:15052200-Cerebrovascular Circulation,
pubmed-meshheading:15052200-Disease Models, Animal,
pubmed-meshheading:15052200-Endothelium, Vascular,
pubmed-meshheading:15052200-Enzyme Activation,
pubmed-meshheading:15052200-Enzyme Inhibitors,
pubmed-meshheading:15052200-Heart Arrest, Induced,
pubmed-meshheading:15052200-Hypothermia, Induced,
pubmed-meshheading:15052200-Immunohistochemistry,
pubmed-meshheading:15052200-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:15052200-Mitogen-Activated Protein Kinases,
pubmed-meshheading:15052200-Models, Cardiovascular,
pubmed-meshheading:15052200-Neurons,
pubmed-meshheading:15052200-Nitriles,
pubmed-meshheading:15052200-Postoperative Complications,
pubmed-meshheading:15052200-Signal Transduction,
pubmed-meshheading:15052200-Swine,
pubmed-meshheading:15052200-Treatment Outcome
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pubmed:year |
2004
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pubmed:articleTitle |
Blockade of the extracellular signal-regulated kinase pathway by U0126 attenuates neuronal damage following circulatory arrest.
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pubmed:affiliation |
Vanderbilt University Medical Center, Nashville, TN 37232, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Evaluation Studies
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