Source:http://linkedlifedata.com/resource/pubmed/id/15051150
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2004-3-30
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| pubmed:abstractText |
Although ethanol has been reported to inhibit the induction of long-term potentiation in hippocampal CA1 and dentate gyrus synapses of rats, very little is known about the effect of ethanol on synaptic plasticity in other brain regions. Therefore, in the present study, we investigated the effect of ethanol on long-term potentiation in synaptic pathway from the basolateral amygdala to the dentate gyrus by using anesthetized rats in vivo. I.v. (20-40% x 2 ml/kg) or i.c.v. (30-40% x 5 microl) administration of ethanol did not affect the basal amplitude of dentate gyrus field potential evoked by basolateral amygdala stimulation, but significantly inhibited the induction of long-term potentiation following application of tetanic stimulation. Since long-term potentiation in this pathway was independent of N-methyl-d-aspartate receptors, the inhibitory effect of ethanol is unlikely to be caused by suppression of N-methyl-d-aspartate receptor function. Alternatively, long-term potentiation in this pathway was significantly suppressed by the benzodiazepine agonist diazepam (2 mg/kg, i.p.), and the inhibitory effect of ethanol was abolished by the GABAA receptor channel blocker picrotoxin (1 mg/kg, i.p.). The present study demonstrates that ethanol inhibits the induction of long-term potentiation in the basolateral amygdala-dentate gyrus pathway by enhancing GABAA receptor-mediated neurotransmission.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
0306-4522
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
125
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
113-7
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| pubmed:meshHeading |
pubmed-meshheading:15051150-Amygdala,
pubmed-meshheading:15051150-Animals,
pubmed-meshheading:15051150-Central Nervous System Depressants,
pubmed-meshheading:15051150-Dentate Gyrus,
pubmed-meshheading:15051150-Ethanol,
pubmed-meshheading:15051150-Evoked Potentials,
pubmed-meshheading:15051150-Long-Term Potentiation,
pubmed-meshheading:15051150-Male,
pubmed-meshheading:15051150-Neural Pathways,
pubmed-meshheading:15051150-Neuronal Plasticity,
pubmed-meshheading:15051150-Rats,
pubmed-meshheading:15051150-Rats, Wistar,
pubmed-meshheading:15051150-Receptors, GABA-A
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| pubmed:year |
2004
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| pubmed:articleTitle |
GABAA receptor-mediated inhibition by ethanol of long-term potentiation in the basolateral amygdala-dentate gyrus pathway in vivo.
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| pubmed:affiliation |
Department of Pharmacology, School of Pharmacy, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. abe@hoshi.ac.jp
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| pubmed:publicationType |
Journal Article
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