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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2004-3-30
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pubmed:abstractText |
(S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide ((S)-2) was identified as a potent and efficacious KCNQ2 opener. This compound demonstrated significant activity in reducing neuronal hyperexcitability in rat hippocampal slices, and the inhibition mediated by (S)-2 was reversed by the KCNQ blocker linopirdine.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BoissardChristopher GCG,
pubmed-author:ChenJieJ,
pubmed-author:DworetzkySteven ISI,
pubmed-author:FitzpatrickWilliamW,
pubmed-author:GribkoffValentin KVK,
pubmed-author:HardenDavid GDG,
pubmed-author:HeHuanH,
pubmed-author:HugWW,
pubmed-author:KnoxRonald JRJ,
pubmed-author:NataleJoanneJ,
pubmed-author:PieschlRick LRL,
pubmed-author:StarrettJohn EJEJr,
pubmed-author:SunLi-QiangLQ,
pubmed-author:ThompsonMarkM,
pubmed-author:WeaverDavidD,
pubmed-author:WuDedongD,
pubmed-author:WuYong-JinYJ
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1991-5
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:15050644-Acrylamides,
pubmed-meshheading:15050644-Animals,
pubmed-meshheading:15050644-Dose-Response Relationship, Drug,
pubmed-meshheading:15050644-Hippocampus,
pubmed-meshheading:15050644-Humans,
pubmed-meshheading:15050644-KCNQ2 Potassium Channel,
pubmed-meshheading:15050644-Kidney,
pubmed-meshheading:15050644-Mice,
pubmed-meshheading:15050644-Molecular Structure,
pubmed-meshheading:15050644-Neurons,
pubmed-meshheading:15050644-Oxazines,
pubmed-meshheading:15050644-Patch-Clamp Techniques,
pubmed-meshheading:15050644-Potassium Channels,
pubmed-meshheading:15050644-Potassium Channels, Voltage-Gated,
pubmed-meshheading:15050644-Rats,
pubmed-meshheading:15050644-Structure-Activity Relationship
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pubmed:year |
2004
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pubmed:articleTitle |
(S)-N-[1-(4-cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide is a potent and efficacious KCNQ2 opener which inhibits induced hyperexcitability of rat hippocampal neurons.
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pubmed:affiliation |
Department of Neuroscience Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, USA. yong-jin.wu@bms.com
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pubmed:publicationType |
Journal Article
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