Linked Life Data

15050289

Source:http://linkedlifedata.com/resource/pubmed/id/15050289

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2004-3-30
pubmed:abstractText
Aging is associated with progressive decline in T cell functions and increased frequency of infections, autoimmune phenomenon, and cancer. Memory T cells rapidly acquire effector functions to kill infected and malignant cells and/or inhibit their replication. Recently, memory T cells have been further classified into central and effector memory T cells (and early and intermediate T cells by some investigators). In aging, memory T cells are accumulated; however, these subpopulations of memory and effector T cells have not been fully characterized and changes in central memory and effector memory T cells in aged humans have not been described. In this article, we have further defined naïve, central memory, effector memory, and effector CD8+ T cells in humans and their changes in aged humans.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0531-5565
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
545-50
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Characterization of naïve, memory and effector CD8+ T cells: effect of age.
pubmed:affiliation
Division of Basic and Clinical Immunology, Medical Sciences C C-240, University of California, Irvine, CA 92697 4069, USA. sgupta@uci.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review