Source:http://linkedlifedata.com/resource/pubmed/id/15050108
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2004-3-30
|
| pubmed:abstractText |
Sudden Infant Death Syndrome is characterized globally by a 50% excess in males per 1000 live births of each gender. We previously hypothesized that this male excess may arise from a single X-linked gene locus with a dominant allele (p = 1/3) that is protective against potentially terminal cerebral anoxia by catalyzing anaerobic oxidation and a recessive allele (q = 2/3) that is unprotective. We now hypothesize this same terminal mechanism for all other causes of infant respiratory death (50% male excess) and that infant cardiac death is equally probable for males and females (0% male excess). With these hypotheses, we model the male excess of all infant mortality (under 5 years) as 25% per 1000 live births of each gender. We show for the USA (1979-2000) that this model of a 25% male excess accurately predicts the male excess mortality under 1 year (24.15%), from 1 to 4 years (25.42%), and under 5 years (24.51%).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0306-9877
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
62
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
564-7
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:15050108-Cause of Death,
pubmed-meshheading:15050108-Child, Preschool,
pubmed-meshheading:15050108-Chromosomes, Human, X,
pubmed-meshheading:15050108-Female,
pubmed-meshheading:15050108-Genetic Linkage,
pubmed-meshheading:15050108-Humans,
pubmed-meshheading:15050108-Infant,
pubmed-meshheading:15050108-Infant, Newborn,
pubmed-meshheading:15050108-Infant Mortality,
pubmed-meshheading:15050108-Male,
pubmed-meshheading:15050108-Models, Genetic,
pubmed-meshheading:15050108-Predictive Value of Tests,
pubmed-meshheading:15050108-Pregnancy,
pubmed-meshheading:15050108-Pregnancy Outcome,
pubmed-meshheading:15050108-Reproducibility of Results,
pubmed-meshheading:15050108-Retrospective Studies,
pubmed-meshheading:15050108-Sex Characteristics,
pubmed-meshheading:15050108-Sex Ratio,
pubmed-meshheading:15050108-Sudden Infant Death,
pubmed-meshheading:15050108-United States
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
The X-linkage hypotheses for SIDS and the male excess in infant mortality.
|
| pubmed:affiliation |
Institute for Survey Research, Temple University, 1601 N. Broad Street, Philadelphia, PA 19122-6099, USA. david.mage@temple.edu
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|