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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-3-30
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pubmed:abstractText |
Schiff bases of N-methyl and N-acetyl isatin derivatives with different aryl amines have been synthesized and screened for anticonvulsant activities against maximal electroshock (MES) and subcutaneous metrazole (ScMet). N-methyl-5-bromo-3-(p-chlorophenylimino) isatin (2) exhibited anticonvulsant activity in MES and ScMet with LD50 > 600 mg kg(-1), showing better activity than the standard drugs phenytoin, carbamazepine and valproic acid. Thus, compound 2 may be chosen as a prototype for development of new anticonvulsants.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1330-0075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
49-56
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15050044-Animals,
pubmed-meshheading:15050044-Anticonvulsants,
pubmed-meshheading:15050044-Convulsants,
pubmed-meshheading:15050044-Electroshock,
pubmed-meshheading:15050044-Female,
pubmed-meshheading:15050044-Isatin,
pubmed-meshheading:15050044-Lethal Dose 50,
pubmed-meshheading:15050044-Magnetic Resonance Spectroscopy,
pubmed-meshheading:15050044-Male,
pubmed-meshheading:15050044-Mice,
pubmed-meshheading:15050044-Neurotoxicity Syndromes,
pubmed-meshheading:15050044-Pentylenetetrazole,
pubmed-meshheading:15050044-Postural Balance,
pubmed-meshheading:15050044-Schiff Bases,
pubmed-meshheading:15050044-Seizures,
pubmed-meshheading:15050044-Spectrophotometry, Infrared,
pubmed-meshheading:15050044-Structure-Activity Relationship
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pubmed:year |
2004
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pubmed:articleTitle |
Anticonvulsant activity of Schiff bases of isatin derivatives.
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pubmed:affiliation |
Department of Applied Chemistry, Institute of Technology, Banaras Hindu University, Varanasi-221005, India.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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