Source:http://linkedlifedata.com/resource/pubmed/id/15049678
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
7
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pubmed:dateCreated |
2004-3-30
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pubmed:abstractText |
The preparative and stereoselective synthesis (45-50% overall yields) of the target compound 17 has been accomplished from D-ribose. The bulky protecting groups such as TBDPS and Trityl enforced the facial selectivity during Grignard reaction to give the tertiary beta-allylic alcohol 16 as the sole product, which was oxidatively rearranged to the key molecule 17 in excellent yield.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-3263
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2634-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15049678-Adenosine,
pubmed-meshheading:15049678-Catalysis,
pubmed-meshheading:15049678-Chemistry, Organic,
pubmed-meshheading:15049678-Molecular Structure,
pubmed-meshheading:15049678-Nucleosides,
pubmed-meshheading:15049678-Oxidation-Reduction,
pubmed-meshheading:15049678-Ribose,
pubmed-meshheading:15049678-Stereoisomerism,
pubmed-meshheading:15049678-Structure-Activity Relationship
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pubmed:year |
2004
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pubmed:articleTitle |
Preparative and stereoselective synthesis of the versatile intermediate for carbocyclic nucleosides: effects of the bulky protecting groups to enforce facial selectivity.
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pubmed:affiliation |
Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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