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pubmed-article:15048767pubmed:abstractTextSequential polydepsipeptides were synthesized by the depsipeptide active ester method using a new approach for the direct synthesis of N-protected depsipeptide free acids from hydroxy acids. The method uses synthesis of Boc-didepsipeptides by reaction of free hydroxy acids with Boc-amino acid N-hydroxysuccinimide esters catalyzed by 4-dimethylaminopyridine and chain elongation of the free depsipeptides by the reaction with Boc-amino acid N-hydroxysuccinimide esters in an organic solvent system of acetonitrile-tetrahydrofuran. The Boc-depsipeptide free acids were activated as their N-hydroxysuccinimide esters, which were polymerized after removal of the Boc-protecting group.lld:pubmed
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pubmed-article:15048767pubmed:authorpubmed-author:KobayashiKyok...lld:pubmed
pubmed-article:15048767pubmed:authorpubmed-author:YamadaKeiichi...lld:pubmed
pubmed-article:15048767pubmed:authorpubmed-author:OkuHiroyukiHlld:pubmed
pubmed-article:15048767pubmed:authorpubmed-author:KatakaiRyoich...lld:pubmed
pubmed-article:15048767pubmed:authorpubmed-author:EmoriNobuNlld:pubmed
pubmed-article:15048767pubmed:copyrightInfoCopyright 2004 Wiley Periodicals, Inc.lld:pubmed
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pubmed-article:15048767pubmed:day15lld:pubmed
pubmed-article:15048767pubmed:volume73lld:pubmed
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pubmed-article:15048767pubmed:articleTitleSynthesis of sequential polydepsipeptides utilizing a new approach for the synthesis of depsipeptides.lld:pubmed
pubmed-article:15048767pubmed:affiliationDepartment of Chemistry, Gunma University, Tenjin-cho, Kiryu 376-8515, Japan. katakai@chem.gunma-u.ac.jplld:pubmed
pubmed-article:15048767pubmed:publicationTypeJournal Articlelld:pubmed
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