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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2004-3-29
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pubmed:abstractText |
Sequential polydepsipeptides were synthesized by the depsipeptide active ester method using a new approach for the direct synthesis of N-protected depsipeptide free acids from hydroxy acids. The method uses synthesis of Boc-didepsipeptides by reaction of free hydroxy acids with Boc-amino acid N-hydroxysuccinimide esters catalyzed by 4-dimethylaminopyridine and chain elongation of the free depsipeptides by the reaction with Boc-amino acid N-hydroxysuccinimide esters in an organic solvent system of acetonitrile-tetrahydrofuran. The Boc-depsipeptide free acids were activated as their N-hydroxysuccinimide esters, which were polymerized after removal of the Boc-protecting group.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0006-3525
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2004 Wiley Periodicals, Inc.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
641-4
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pubmed:meshHeading |
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pubmed:year |
2004
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pubmed:articleTitle |
Synthesis of sequential polydepsipeptides utilizing a new approach for the synthesis of depsipeptides.
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pubmed:affiliation |
Department of Chemistry, Gunma University, Tenjin-cho, Kiryu 376-8515, Japan. katakai@chem.gunma-u.ac.jp
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pubmed:publicationType |
Journal Article
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