| pubmed-article:1504730 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1504730 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1504730 | lifeskim:mentions | umls-concept:C0234421 | lld:lifeskim |
| pubmed-article:1504730 | lifeskim:mentions | umls-concept:C0042402 | lld:lifeskim |
| pubmed-article:1504730 | lifeskim:mentions | umls-concept:C0006669 | lld:lifeskim |
| pubmed-article:1504730 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:1504730 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:1504730 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1504730 | pubmed:dateCreated | 1992-9-22 | lld:pubmed |
| pubmed-article:1504730 | pubmed:abstractText | 1. The aim of this study was to investigate whether the hypotensive effect of rat alpha-calcitonin gene-related peptide (alpha CGRP) in conscious rats is mediated by endothelium-derived nitric oxide (NO) or the opening of adenosine 5'-triphosphate (ATP)-sensitive potassium (KATP) channels. 2. Dose-mean arterial pressure (MAP)-response curves of alpha CGRP were examined in the presence of vehicle, phenylephrine, KATP channel antagonist glibenclamide or NO synthase inhibitors, NG-nitro-L-arginine methyl ester (L-NAME) and NG-nitro-D-arginine methyl ester (D-NAME). Dose-MAP-response curves for sodium nitroprusside were also constructed in the presence and absence of L-NAME and D-NAME. 3. alpha CGRP and nitroprusside produced dose-dependent reductions in MAP which were potentiated by phenylephrine. Both L-NAME and D-NAME attenuated the depressor response to alpha CGRP but not nitroprusside. 4. Dose-MAP-response curves for pinacidil, a KATP-channel activator, were also examined in the presence of glibenclamide or vehicle. Glibenclamide attenuated pinacidil- but not alpha CGRP-induced reductions in MAP. 5. It is concluded that the hypotensive effects of alpha CGRP are partially mediated via endothelium-derived NO but not via the opening of KATP channels. | lld:pubmed |
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| pubmed-article:1504730 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:1504730 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1504730 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1504730 | pubmed:month | May | lld:pubmed |
| pubmed-article:1504730 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:1504730 | pubmed:author | pubmed-author:MELOM JMJ | lld:pubmed |
| pubmed-article:1504730 | pubmed:author | pubmed-author:ChangS DSD | lld:pubmed |
| pubmed-article:1504730 | pubmed:author | pubmed-author:WangY XYX | lld:pubmed |
| pubmed-article:1504730 | pubmed:author | pubmed-author:AbdelrahmanAA | lld:pubmed |
| pubmed-article:1504730 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1504730 | pubmed:volume | 106 | lld:pubmed |
| pubmed-article:1504730 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1504730 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1504730 | pubmed:pagination | 45-8 | lld:pubmed |
| pubmed-article:1504730 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1504730 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1504730 | pubmed:articleTitle | Mechanism of the vasodilator action of calcitonin gene-related peptide in conscious rats. | lld:pubmed |
| pubmed-article:1504730 | pubmed:affiliation | Department of Pharmacology & Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, Canada. | lld:pubmed |
| pubmed-article:1504730 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1504730 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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