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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1992-9-22
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pubmed:abstractText |
1. The aim of this study was to investigate whether the hypotensive effect of rat alpha-calcitonin gene-related peptide (alpha CGRP) in conscious rats is mediated by endothelium-derived nitric oxide (NO) or the opening of adenosine 5'-triphosphate (ATP)-sensitive potassium (KATP) channels. 2. Dose-mean arterial pressure (MAP)-response curves of alpha CGRP were examined in the presence of vehicle, phenylephrine, KATP channel antagonist glibenclamide or NO synthase inhibitors, NG-nitro-L-arginine methyl ester (L-NAME) and NG-nitro-D-arginine methyl ester (D-NAME). Dose-MAP-response curves for sodium nitroprusside were also constructed in the presence and absence of L-NAME and D-NAME. 3. alpha CGRP and nitroprusside produced dose-dependent reductions in MAP which were potentiated by phenylephrine. Both L-NAME and D-NAME attenuated the depressor response to alpha CGRP but not nitroprusside. 4. Dose-MAP-response curves for pinacidil, a KATP-channel activator, were also examined in the presence of glibenclamide or vehicle. Glibenclamide attenuated pinacidil- but not alpha CGRP-induced reductions in MAP. 5. It is concluded that the hypotensive effects of alpha CGRP are partially mediated via endothelium-derived NO but not via the opening of KATP channels.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1504730-1688944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1504730-1706208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1504730-1718522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1504730-1769375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1504730-1878760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1504730-2109832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1504730-2243334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1504730-2459371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1504730-2464055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1504730-2474355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1504730-2501869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1504730-2551879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1504730-2822189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1504730-2998368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1504730-3501322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1504730-3917554
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Antihypertensive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Arginine,
http://linkedlifedata.com/resource/pubmed/chemical/Calcitonin Gene-Related Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Glyburide,
http://linkedlifedata.com/resource/pubmed/chemical/Guanidines,
http://linkedlifedata.com/resource/pubmed/chemical/NG-Nitroarginine Methyl Ester,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroprusside,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Pinacidil,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
45-8
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1504730-Adenosine Triphosphate,
pubmed-meshheading:1504730-Analysis of Variance,
pubmed-meshheading:1504730-Animals,
pubmed-meshheading:1504730-Antihypertensive Agents,
pubmed-meshheading:1504730-Arginine,
pubmed-meshheading:1504730-Blood Pressure,
pubmed-meshheading:1504730-Calcitonin Gene-Related Peptide,
pubmed-meshheading:1504730-Glyburide,
pubmed-meshheading:1504730-Guanidines,
pubmed-meshheading:1504730-Male,
pubmed-meshheading:1504730-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:1504730-Nitric Oxide,
pubmed-meshheading:1504730-Nitroprusside,
pubmed-meshheading:1504730-Phenylephrine,
pubmed-meshheading:1504730-Pinacidil,
pubmed-meshheading:1504730-Potassium Channels,
pubmed-meshheading:1504730-Rats,
pubmed-meshheading:1504730-Rats, Inbred Strains,
pubmed-meshheading:1504730-Vasodilator Agents
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pubmed:year |
1992
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pubmed:articleTitle |
Mechanism of the vasodilator action of calcitonin gene-related peptide in conscious rats.
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pubmed:affiliation |
Department of Pharmacology & Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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