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rdf:type |
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lifeskim:mentions |
umls-concept:C0007600,
umls-concept:C0017262,
umls-concept:C0029925,
umls-concept:C0185117,
umls-concept:C0205314,
umls-concept:C0679622,
umls-concept:C0762434,
umls-concept:C0851827,
umls-concept:C1280500,
umls-concept:C1335238,
umls-concept:C1518174,
umls-concept:C1701901,
umls-concept:C1883254,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
2004-3-29
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pubmed:abstractText |
Despite the advent of new chemotherapeutic drugs in recent decades, epithelial ovarian carcinoma (EOC) remains the leading cause of death from gynecologic cancers, and new therapeutic targets and agents are urgently needed. 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO) is a novel synthetic triterpenoid with anti-tumor activity against a wide range of tumors in vitro and in vivo. CDDO is a ligand for the peroxisome proliferator-activated receptor-gamma (PPARgamma). The aim of the present study was to evaluate CDDO activity in EOC cell lines in vitro.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0090-8258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
149-54
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15047229-Antineoplastic Agents,
pubmed-meshheading:15047229-Cell Division,
pubmed-meshheading:15047229-Cell Line, Tumor,
pubmed-meshheading:15047229-Female,
pubmed-meshheading:15047229-Growth Inhibitors,
pubmed-meshheading:15047229-Humans,
pubmed-meshheading:15047229-Oleanolic Acid,
pubmed-meshheading:15047229-Ovarian Neoplasms,
pubmed-meshheading:15047229-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:15047229-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15047229-Transcription Factors
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pubmed:year |
2004
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pubmed:articleTitle |
Growth-inhibitory effect of a novel synthetic triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, on ovarian carcinoma cell lines not dependent on peroxisome proliferator-activated receptor-gamma expression.
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pubmed:affiliation |
Department of Gynecologic Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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