Source:http://linkedlifedata.com/resource/pubmed/id/15044258
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2004-9-2
|
| pubmed:abstractText |
Primary systemic amyloidosis (AL) is a fatal plasma cell disorder. Pilot data suggest survival is better in patients undergoing peripheral blood stem cell transplantation (PBSCT), but the selection process makes the apparent benefit suspect. We have reported that circulating cardiac biomarkers are the best predictors of survival outside of the transplantation setting. We now test whether cardiac troponins (cTnT and cTnI) and N-terminal pro-brain natriuretic peptide (NT-proBNP) are prognostic in transplant recipients. In 98 patients with AL undergoing PBSCT, serum cardiac biomarkers were measured (cTnT, 98 patients; cTnI, 65 patients; and NT-proBNP, 63 patients). Elevated levels of cTnT, cTnI, and NT-proBNP were present in 14%, 43%, and 48% of patients, respectively. At 20 months median follow-up, median survival has not been reached for patients with values below the thresholds; in patients with values above the thresholds, median survival is 26.1 months, 66.1 months, and 66.1 months, respectively. Our previously reported risk systems incorporating these markers were also prognostic, notably the cTnT/NT-proBNP staging. Using this system, 49%, 38%, and 13% of patients were in stage I, stage II, and stage III, respectively. Determining levels of circulating biomarkers may be the most powerful tool for staging patients with AL undergoing PBSCT.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0006-4971
|
| pubmed:author |
pubmed-author:AnsellStephen MSM,
pubmed-author:BurrittMary FMF,
pubmed-author:DispenzieriAngelaA,
pubmed-author:ElliottMichelle AMA,
pubmed-author:FonsecaRafaelR,
pubmed-author:GastineauDennis ADA,
pubmed-author:GertzMorie AMA,
pubmed-author:GreippPhilip RPR,
pubmed-author:HaymanSusan RSR,
pubmed-author:HoganWilliam JWJ,
pubmed-author:InwardsDavid JDJ,
pubmed-author:JaffeAllan SAS,
pubmed-author:KyleRobert ARA,
pubmed-author:LacyMartha QMQ,
pubmed-author:LitzowMark RMR,
pubmed-author:LustJohn AJA,
pubmed-author:McConnellJoseph PJP,
pubmed-author:McGregorChristopher G ACG,
pubmed-author:MicallefIvana NIN,
pubmed-author:PorrataLuis FLF,
pubmed-author:RajkumarS VincentSV,
pubmed-author:SnowDenise SDS,
pubmed-author:TefferiAyalewA,
pubmed-author:TherneauTerry MTM,
pubmed-author:WitzigThomas ETE,
pubmed-author:ZeldenrustSteven RSR
|
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
104
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1881-7
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:15044258-Adult,
pubmed-meshheading:15044258-Aged,
pubmed-meshheading:15044258-Amyloidosis,
pubmed-meshheading:15044258-Biological Markers,
pubmed-meshheading:15044258-Female,
pubmed-meshheading:15044258-Humans,
pubmed-meshheading:15044258-Logistic Models,
pubmed-meshheading:15044258-Male,
pubmed-meshheading:15044258-Middle Aged,
pubmed-meshheading:15044258-Myocardium,
pubmed-meshheading:15044258-Natriuretic Peptide, Brain,
pubmed-meshheading:15044258-Peripheral Blood Stem Cell Transplantation,
pubmed-meshheading:15044258-Probability,
pubmed-meshheading:15044258-Prognosis,
pubmed-meshheading:15044258-Survival Rate,
pubmed-meshheading:15044258-Time Factors,
pubmed-meshheading:15044258-Troponin
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Prognostication of survival using cardiac troponins and N-terminal pro-brain natriuretic peptide in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantation.
|
| pubmed:affiliation |
Division of Hematology and Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. dispenzieri.angela@mayo.edu
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|