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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2004-3-26
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pubmed:abstractText |
The lithistid sponge Scleritoderma nodosum contains a new cyclic peptide, scleritodermin A (1), the structure of which incorporates l-proline, l-serine, and keto-allo-isoleucine units as well as a novel conjugated thiazole moiety (ACT) and O-methyl-N-sulfoserine. Scleritodermin A (1) inhibited tubulin polymerization and showed significant in vitro cytotoxicity against human tumor cell lines.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0163-3864
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
475-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15043437-Animals,
pubmed-meshheading:15043437-Antineoplastic Agents,
pubmed-meshheading:15043437-Brain,
pubmed-meshheading:15043437-Cattle,
pubmed-meshheading:15043437-Cell Cycle,
pubmed-meshheading:15043437-Cell Line, Tumor,
pubmed-meshheading:15043437-Drug Screening Assays, Antitumor,
pubmed-meshheading:15043437-Female,
pubmed-meshheading:15043437-Humans,
pubmed-meshheading:15043437-Molecular Structure,
pubmed-meshheading:15043437-Nuclear Magnetic Resonance, Biomolecular,
pubmed-meshheading:15043437-Oceans and Seas,
pubmed-meshheading:15043437-Peptides, Cyclic,
pubmed-meshheading:15043437-Porifera,
pubmed-meshheading:15043437-Tubulin Modulators,
pubmed-meshheading:15043437-Tumor Cells, Cultured,
pubmed-meshheading:15043437-Vinblastine
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pubmed:year |
2004
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pubmed:articleTitle |
Scleritodermin A, a cytotoxic cyclic peptide from the lithistid sponge Scleritoderma nodosum.
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pubmed:affiliation |
Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0212, USA. ews1@utah.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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