Linked Life Data

15042838

Source:http://linkedlifedata.com/resource/pubmed/id/15042838

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-3-26
pubmed:abstractText
This review of the original works on computer analysis of the human genome considers the development of methods to predict the exon-intron structure of genes and analysis of alternative splicing. Prediction of the gene structure is based on homology between the gene product and a known protein or between the genomic sequences of the gene and its homolog from another organism. The methods were tested and proved highly efficient. Human gene splicing was analyzed with original methods and EST databases. Genes with alternative splicing were for the first time shown to account for no less than 35% total genes. Alternative splicing was compared for the human and mouse genomes. Species-specific isoforms were demonstrated for 50% alternatively spliced genes (25% total genes).
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0026-8984
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
82-91
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[Prediction and computer analysis of the exon-intron structure of human genes].
pubmed:affiliation
State Research Center, GosNIIgenetika, Moscow, 113545 Russia. aa.mironov@pochtamt.ru
pubmed:publicationType
Journal Article, English Abstract