Source:http://linkedlifedata.com/resource/pubmed/id/15042301
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2004-3-25
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| pubmed:abstractText |
The indication for an initial cranial computed tomography (CCT) in minor head trauma (MHT) patients remains the subject of discussion. The aim of this study was to investigate whether a newly developed, rapid test system (ELECSYS S100, Roche Diagnostics) might allow a diagnostically valid, reproducible measurement of S 100 in MHT patients. Blood samples were drawn from 75 MHT patients, a CCT scan was performed, and those with a post-traumatic intracranial lesion counted as CCT+. Results were compared to a healthy control group (n=17). Of the 75 patients included in the study, 14 were stratified as CCT+. The systemic concentration of S 100 in these CCT+ patients was significantly increased (0.31 microg/l) compared to the healthy control group (0.04 microg/l) as well as to the CCT-negative patients (0.08 microg/l). The ELECSYS S100 system allows a rapid, valid, and reproducible assessment of S 100B in patient serum and this concentration is significantly elevated in patients suffering from intracranial lesions as shown by initial CCT scan. Hence, this study is the basis for a multicenter trial currently underway to confirm the results of our pilot study.
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| pubmed:language |
ger
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0177-5537
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
107
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
197-202
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| pubmed:dateRevised |
2009-11-3
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| pubmed:meshHeading |
pubmed-meshheading:15042301-Adult,
pubmed-meshheading:15042301-Biological Markers,
pubmed-meshheading:15042301-Brain Edema,
pubmed-meshheading:15042301-Brain Hemorrhage, Traumatic,
pubmed-meshheading:15042301-Emergencies,
pubmed-meshheading:15042301-Female,
pubmed-meshheading:15042301-Head Injuries, Closed,
pubmed-meshheading:15042301-Humans,
pubmed-meshheading:15042301-Male,
pubmed-meshheading:15042301-Middle Aged,
pubmed-meshheading:15042301-Pilot Projects,
pubmed-meshheading:15042301-Prospective Studies,
pubmed-meshheading:15042301-Reagent Kits, Diagnostic,
pubmed-meshheading:15042301-Reference Values,
pubmed-meshheading:15042301-Reproducibility of Results,
pubmed-meshheading:15042301-S100 Proteins,
pubmed-meshheading:15042301-Sensitivity and Specificity,
pubmed-meshheading:15042301-Skull Fractures,
pubmed-meshheading:15042301-Tomography, X-Ray Computed
|
| pubmed:year |
2004
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| pubmed:articleTitle |
[Identification of high-risk patients after minor craniocerebral trauma. Measurement of nerve tissue protein S 100].
|
| pubmed:affiliation |
Chirurgische Klinik und Poliklinik-Innenstadt, Ludwig-Maximilians-Universität, Nussbaumstrasse 20, 80336 Munich, Germany. peter.biberthaler@med.uni-muenchen.de
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| pubmed:publicationType |
Journal Article,
English Abstract
|