Source:http://linkedlifedata.com/resource/pubmed/id/15041229
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2004-3-25
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pubmed:abstractText |
We report a case of childhood de novo acute myelocytic leukemia (AML) with hyperleukocytosis with monoblastic features and deranged hemostasic function. G-band karyotyping demonstrated a previously unreported t(11;13)(q23;q14) in metaphase preparations from a fluorodeoxyuridine synchronized 1-day culture of leukophoresed cells. Multicolor fluorescence in situ hybridization revealed no cryptic rearrangements except for the translocation. Reverse transcriptase polymerase chain reaction showed no concomitant positivity of AML1/ETO, BCR/ABL, PML/RARA, and CBFbeta/MYH11 resulting from t(8;21)(q22;q22), t(9;22)(q34;q11), t(15;17)(q22;q11), and inv(16) (p13q22), respectively. This report of childhood de novo AML harboring t(11;13)(q23;q14) as the sole cytogenetic abnormality provides more data on the leukemogenesis of de novo AML with a 11q23 rearrangement.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0165-4608
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
150
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
78-80
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15041229-Child,
pubmed-meshheading:15041229-Chromosome Aberrations,
pubmed-meshheading:15041229-Chromosome Banding,
pubmed-meshheading:15041229-Chromosomes, Human, Pair 11,
pubmed-meshheading:15041229-Chromosomes, Human, Pair 13,
pubmed-meshheading:15041229-Female,
pubmed-meshheading:15041229-Gene Rearrangement,
pubmed-meshheading:15041229-Humans,
pubmed-meshheading:15041229-In Situ Hybridization, Fluorescence,
pubmed-meshheading:15041229-Karyotyping,
pubmed-meshheading:15041229-Leukemia, Myeloid, Acute,
pubmed-meshheading:15041229-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15041229-Translocation, Genetic,
pubmed-meshheading:15041229-Tumor Markers, Biological
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pubmed:year |
2004
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pubmed:articleTitle |
Translocation (11;13)(q23;q14) as the sole abnormality in a childhood de novo acute myelocytic leukemia.
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pubmed:affiliation |
Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Ngan Shing Street, Hong Kong, China. tsangks@cuhk.edu.hk
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pubmed:publicationType |
Journal Article,
Case Reports
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