Linked Life Data

15041147

Source:http://linkedlifedata.com/resource/pubmed/id/15041147

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-3-25
pubmed:abstractText
Pharmaceuticals have been reported in surface waters, prompting legitimate public concern, as pharmaceuticals are biologically active compounds used daily by the public. Currently there are ecotoxicological data available for <1%, thus, the European Union Commission's Scientific committee on Toxicity, Ecotoxicity, and Environment (CSTEE) recommended use of (Q)SAR models and precaution to prioritize further risk assessment of approximately 4500 compounds and their adjuvants. We ranked 2986 different pharmaceutical compounds in 51 classes relative to hazard toward algae, daphnids, and fish using the EPIWIN program. This ranking cannot be used to acquit a compound based on predicted relative ranking. Modifying additives were the most toxic classes. Cardiovascular, gastrointestinal, antiviral, anxiolytic sedatives hypnotics and antipsychotics, corticosteroid, and thyroid pharmaceuticals were the predicted most hazardous therapeutic classes. The overall relative order of susceptibility was estimated to be daphnids > fish > algae. Expert judgment is needed to assess specific hazards for classes like microbial resistance and antibiotics, sex hormones, and endocrine disruptors. As human health and the function of ecological systems are interconnected and subject to the precautionary principle, harmonization of evidence for correlation and causality of adverse effects seems sensible in an ethical and cost-effective context to facilitate substitution of hazardous compounds. Data available: http://www.uoguelph.ca/~hsander/.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0273-2300
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
158-83
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Ranking and prioritization of environmental risks of pharmaceuticals in surface waters.
pubmed:affiliation
Centre for Toxicology, University of Guelph, Bovey Building, Guelph, Ont., Canada N1G 2W1. hsander@uoguelph.ca
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't