Linked Life Data

150405

Source:http://linkedlifedata.com/resource/pubmed/id/150405

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1978-10-27
pubmed:abstractText
The effects of aggregated human IgG, human anti-Ia-like antibody, and anti-beta2-microglobulin on mixed lymphocyte culture (MLC) were studied. Aggregated human IgG inhibited both stimulatory and responding activities in MLC. When Fc-receptor-bearing cells were removed from responding cells, the inhibitory activity of aggregated IgG was markedly reduced. The result suggested that the inhibition of MLC by aggregated IgG is primarily based on the blocking of Fc-receptor-bearing cells contained in the stimulator cells. In addition, the removal of Fc-receptor-bearing cells from stimulatory cells resulted in the loss of MLC response. Anti-Ia-like antibodies contained in anti-HLA sera and B-cell-specific human alloantisera also inhibited stimulatory activities in MLC. Rabbit antiserum against human beta2-microglobulin showed inhibitions of both stimulatory and responding activities. These results suggested the close association of human MLC stimulator site with Fc receptor and Ia-like antigen and also some relation of beta2-microglobulin with MLC reaction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0020-5915
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
521-8
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Close association of human mixed lymphocyte culture antigen, Ia-like antigen and Fc receptor.
pubmed:publicationType
Journal Article